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Single-Fraction Radiotherapy for CD30(+) Lymphoproliferative Disorders
Objectives. CD30(+) lymphoproliferative disorder is a rare variant of cutaneous T-cell lymphoma. Sustained complete response following first-line treatments is rare. This retrospective review evaluates the response of refractory or recurrent lesions to palliative radiation therapy. Methods. The reco...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4609348/ https://www.ncbi.nlm.nih.gov/pubmed/26504818 http://dx.doi.org/10.1155/2015/629587 |
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author | Gentile, Michelle S. Martinez-Escala, Maria Estela Thomas, Tarita O. Guitart, Joan Rosen, Steven Kuzel, Timothy Mittal, Bharat B. |
author_facet | Gentile, Michelle S. Martinez-Escala, Maria Estela Thomas, Tarita O. Guitart, Joan Rosen, Steven Kuzel, Timothy Mittal, Bharat B. |
author_sort | Gentile, Michelle S. |
collection | PubMed |
description | Objectives. CD30(+) lymphoproliferative disorder is a rare variant of cutaneous T-cell lymphoma. Sustained complete response following first-line treatments is rare. This retrospective review evaluates the response of refractory or recurrent lesions to palliative radiation therapy. Methods. The records of 6 patients with 12 lesions, treated with radiation therapy, were reviewed. All patients received previous first-line treatments. Patients with clinical and pathological evidence of symptomatic CD30(+) lymphoproliferative disorder, with no history of other cutaneous T-cell lymphoma variants, and with no prior radiation therapy to the index site were included. Results. The median age of patients was 50.5 years (range, 15–83 years). Median size of the treated lesions was 2.5 cm (range, 2–7 cm). Four sites were treated with a single fraction of 750–800 cGy (n = 3) and 8 sites were treated with 4000–4500 cGy in 200–250 cGy fractions (n = 3). Radiation therapy was administered with electrons and bolus. Median follow-up was 113 months (range, 16–147 months). For all sites, there was 100% complete response with acute grade 1-2 dermatitis. Conclusions. For recurrent and symptomatic radiation-naïve CD30(+) lymphoproliferative disorder lesions, palliative radiation therapy shows excellent response. A single fraction of 750–800 cGy is as effective as a multifractionated course and more convenient. |
format | Online Article Text |
id | pubmed-4609348 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-46093482015-10-26 Single-Fraction Radiotherapy for CD30(+) Lymphoproliferative Disorders Gentile, Michelle S. Martinez-Escala, Maria Estela Thomas, Tarita O. Guitart, Joan Rosen, Steven Kuzel, Timothy Mittal, Bharat B. Biomed Res Int Research Article Objectives. CD30(+) lymphoproliferative disorder is a rare variant of cutaneous T-cell lymphoma. Sustained complete response following first-line treatments is rare. This retrospective review evaluates the response of refractory or recurrent lesions to palliative radiation therapy. Methods. The records of 6 patients with 12 lesions, treated with radiation therapy, were reviewed. All patients received previous first-line treatments. Patients with clinical and pathological evidence of symptomatic CD30(+) lymphoproliferative disorder, with no history of other cutaneous T-cell lymphoma variants, and with no prior radiation therapy to the index site were included. Results. The median age of patients was 50.5 years (range, 15–83 years). Median size of the treated lesions was 2.5 cm (range, 2–7 cm). Four sites were treated with a single fraction of 750–800 cGy (n = 3) and 8 sites were treated with 4000–4500 cGy in 200–250 cGy fractions (n = 3). Radiation therapy was administered with electrons and bolus. Median follow-up was 113 months (range, 16–147 months). For all sites, there was 100% complete response with acute grade 1-2 dermatitis. Conclusions. For recurrent and symptomatic radiation-naïve CD30(+) lymphoproliferative disorder lesions, palliative radiation therapy shows excellent response. A single fraction of 750–800 cGy is as effective as a multifractionated course and more convenient. Hindawi Publishing Corporation 2015 2015-10-04 /pmc/articles/PMC4609348/ /pubmed/26504818 http://dx.doi.org/10.1155/2015/629587 Text en Copyright © 2015 Michelle S. Gentile et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Gentile, Michelle S. Martinez-Escala, Maria Estela Thomas, Tarita O. Guitart, Joan Rosen, Steven Kuzel, Timothy Mittal, Bharat B. Single-Fraction Radiotherapy for CD30(+) Lymphoproliferative Disorders |
title | Single-Fraction Radiotherapy for CD30(+) Lymphoproliferative Disorders |
title_full | Single-Fraction Radiotherapy for CD30(+) Lymphoproliferative Disorders |
title_fullStr | Single-Fraction Radiotherapy for CD30(+) Lymphoproliferative Disorders |
title_full_unstemmed | Single-Fraction Radiotherapy for CD30(+) Lymphoproliferative Disorders |
title_short | Single-Fraction Radiotherapy for CD30(+) Lymphoproliferative Disorders |
title_sort | single-fraction radiotherapy for cd30(+) lymphoproliferative disorders |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4609348/ https://www.ncbi.nlm.nih.gov/pubmed/26504818 http://dx.doi.org/10.1155/2015/629587 |
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