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Prevalence, Risk Factors, and Genetic Traits in Metabolically Healthy and Unhealthy Obese Individuals

Objective. To assess prevalence of metabolically healthy individuals among patients with abdominal obesity (AO) and to determine phenotype and potential genetic traits associated with a benign metabolic status. Methods. 503 AO patients without cardiovascular diseases were examined. Waist circumferen...

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Autores principales: Berezina, A., Belyaeva, O., Berkovich, O., Baranova, E., Karonova, T., Bazhenova, E., Brovin, D., Grineva, E., Shlyakhto, E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4609360/
https://www.ncbi.nlm.nih.gov/pubmed/26504811
http://dx.doi.org/10.1155/2015/548734
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author Berezina, A.
Belyaeva, O.
Berkovich, O.
Baranova, E.
Karonova, T.
Bazhenova, E.
Brovin, D.
Grineva, E.
Shlyakhto, E.
author_facet Berezina, A.
Belyaeva, O.
Berkovich, O.
Baranova, E.
Karonova, T.
Bazhenova, E.
Brovin, D.
Grineva, E.
Shlyakhto, E.
author_sort Berezina, A.
collection PubMed
description Objective. To assess prevalence of metabolically healthy individuals among patients with abdominal obesity (AO) and to determine phenotype and potential genetic traits associated with a benign metabolic status. Methods. 503 AO patients without cardiovascular diseases were examined. Waist circumference (WC), BMI, blood pressure, plasma glucose and serum insulin levels, HOMA-IR, lipid profile, and adiponectin (AN) and leptin (LEP) concentrations in serum were measured. Polymorphisms A19G and Q223R of the LEP and LEP receptor gene, and G276T and T45G of the AN gene were investigated. Results. 91.3% of patients were metabolically unhealthy obese (MUO), and 8.7% metabolically healthy obese (MHO). MHO patients were younger, and had lesser BMI and WC, while duration of obesity, frequency, and duration of physical training were greater than MUO patients (p < 0.05). In MHO and MUO patients distribution of the G19G, G19A, and A19A genotypes of the LEP gene and G276G, G276T, and T276T genotypes of AN gene did not differ. The Т45Т genotype was associated with increase of metabolic disorders' risk for patients with АО (OR = 2.331; 95%  CI = 1.121 ÷ 5.132). Conclusions. Prevalence of MHO individuals among patients with AO is low. Benign metabolic status was associated with younger age, lower waist circumference, and higher physical activity, shorter duration of obesity, and G45G adiponectin genotype carriage.
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spelling pubmed-46093602015-10-26 Prevalence, Risk Factors, and Genetic Traits in Metabolically Healthy and Unhealthy Obese Individuals Berezina, A. Belyaeva, O. Berkovich, O. Baranova, E. Karonova, T. Bazhenova, E. Brovin, D. Grineva, E. Shlyakhto, E. Biomed Res Int Research Article Objective. To assess prevalence of metabolically healthy individuals among patients with abdominal obesity (AO) and to determine phenotype and potential genetic traits associated with a benign metabolic status. Methods. 503 AO patients without cardiovascular diseases were examined. Waist circumference (WC), BMI, blood pressure, plasma glucose and serum insulin levels, HOMA-IR, lipid profile, and adiponectin (AN) and leptin (LEP) concentrations in serum were measured. Polymorphisms A19G and Q223R of the LEP and LEP receptor gene, and G276T and T45G of the AN gene were investigated. Results. 91.3% of patients were metabolically unhealthy obese (MUO), and 8.7% metabolically healthy obese (MHO). MHO patients were younger, and had lesser BMI and WC, while duration of obesity, frequency, and duration of physical training were greater than MUO patients (p < 0.05). In MHO and MUO patients distribution of the G19G, G19A, and A19A genotypes of the LEP gene and G276G, G276T, and T276T genotypes of AN gene did not differ. The Т45Т genotype was associated with increase of metabolic disorders' risk for patients with АО (OR = 2.331; 95%  CI = 1.121 ÷ 5.132). Conclusions. Prevalence of MHO individuals among patients with AO is low. Benign metabolic status was associated with younger age, lower waist circumference, and higher physical activity, shorter duration of obesity, and G45G adiponectin genotype carriage. Hindawi Publishing Corporation 2015 2015-10-04 /pmc/articles/PMC4609360/ /pubmed/26504811 http://dx.doi.org/10.1155/2015/548734 Text en Copyright © 2015 A. Berezina et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Berezina, A.
Belyaeva, O.
Berkovich, O.
Baranova, E.
Karonova, T.
Bazhenova, E.
Brovin, D.
Grineva, E.
Shlyakhto, E.
Prevalence, Risk Factors, and Genetic Traits in Metabolically Healthy and Unhealthy Obese Individuals
title Prevalence, Risk Factors, and Genetic Traits in Metabolically Healthy and Unhealthy Obese Individuals
title_full Prevalence, Risk Factors, and Genetic Traits in Metabolically Healthy and Unhealthy Obese Individuals
title_fullStr Prevalence, Risk Factors, and Genetic Traits in Metabolically Healthy and Unhealthy Obese Individuals
title_full_unstemmed Prevalence, Risk Factors, and Genetic Traits in Metabolically Healthy and Unhealthy Obese Individuals
title_short Prevalence, Risk Factors, and Genetic Traits in Metabolically Healthy and Unhealthy Obese Individuals
title_sort prevalence, risk factors, and genetic traits in metabolically healthy and unhealthy obese individuals
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4609360/
https://www.ncbi.nlm.nih.gov/pubmed/26504811
http://dx.doi.org/10.1155/2015/548734
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