Expression of Stem Cell Markers in Preinvasive Tubal Lesions of Ovarian Carcinoma

In order to better understand the ovarian serous carcinogenic process with tubal origin, we investigated the expression of stem cell markers in premalignant tubal lesions (serous tubal intraepithelial carcinoma or STIC). We found an increased stem cell marker density in the normal fallopian tube fol...

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Detalles Bibliográficos
Autores principales: Chene, G., Ouellet, V., Rahimi, K., Barres, V., Meunier, L., De Ladurantaye, M., Provencher, D., Mes-Masson, A. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4609379/
https://www.ncbi.nlm.nih.gov/pubmed/26504831
http://dx.doi.org/10.1155/2015/808531
Descripción
Sumario:In order to better understand the ovarian serous carcinogenic process with tubal origin, we investigated the expression of stem cell markers in premalignant tubal lesions (serous tubal intraepithelial carcinoma or STIC). We found an increased stem cell marker density in the normal fallopian tube followed by a high CD117 and a low ALDH and CD44 expression in STICs raising the question of the role of the stem cell markers in the serous carcinogenic process.

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