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Monitoring Microcirculatory Blood Flow with a New Sublingual Tonometer in a Porcine Model of Hemorrhagic Shock
Tissue capnometry may be suitable for the indirect evaluation of regional hypoperfusion. We tested the performance of a new sublingual capillary tonometer in experimental hemorrhage. Thirty-six anesthetized, ventilated mini pigs were divided into sham-operated (n = 9) and shock groups (n = 27). Hemo...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4609384/ https://www.ncbi.nlm.nih.gov/pubmed/26504837 http://dx.doi.org/10.1155/2015/847152 |
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author | Palágyi, Péter Kaszaki, József Rostás, Andrea Érces, Dániel Németh, Márton Boros, Mihály Molnár, Zsolt |
author_facet | Palágyi, Péter Kaszaki, József Rostás, Andrea Érces, Dániel Németh, Márton Boros, Mihály Molnár, Zsolt |
author_sort | Palágyi, Péter |
collection | PubMed |
description | Tissue capnometry may be suitable for the indirect evaluation of regional hypoperfusion. We tested the performance of a new sublingual capillary tonometer in experimental hemorrhage. Thirty-six anesthetized, ventilated mini pigs were divided into sham-operated (n = 9) and shock groups (n = 27). Hemorrhagic shock was induced by reducing mean arterial pressure (MAP) to 40 mmHg for 60 min, after which fluid resuscitation started aiming to increase MAP to 75% of the baseline value (60–180 min). Sublingual carbon-dioxide partial pressure was measured by tonometry, using a specially coiled silicone rubber tube. Mucosal red blood cell velocity (RBCV) and capillary perfusion rate (CPR) were assessed by orthogonal polarization spectral (OPS) imaging. In the 60 min shock phase a significant drop in cardiac index was accompanied by reduction in sublingual RBCV and CPR and significant increase in the sublingual mucosal-to-arterial PCO(2) gap (P(SL)CO(2) gap), which significantly improved during the 120 min resuscitation phase. There was significant correlation between P(SL)CO(2) gap and sublingual RBCV (r = −0.65, p < 0.0001), CPR (r = −0.64, p < 0.0001), central venous oxygen saturation (r = −0.50, p < 0.0001), and central venous-to-arterial PCO(2) difference (r = 0.62, p < 0.0001). This new sublingual tonometer may be an appropriate tool for the indirect evaluation of circulatory changes in shock. |
format | Online Article Text |
id | pubmed-4609384 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-46093842015-10-26 Monitoring Microcirculatory Blood Flow with a New Sublingual Tonometer in a Porcine Model of Hemorrhagic Shock Palágyi, Péter Kaszaki, József Rostás, Andrea Érces, Dániel Németh, Márton Boros, Mihály Molnár, Zsolt Biomed Res Int Research Article Tissue capnometry may be suitable for the indirect evaluation of regional hypoperfusion. We tested the performance of a new sublingual capillary tonometer in experimental hemorrhage. Thirty-six anesthetized, ventilated mini pigs were divided into sham-operated (n = 9) and shock groups (n = 27). Hemorrhagic shock was induced by reducing mean arterial pressure (MAP) to 40 mmHg for 60 min, after which fluid resuscitation started aiming to increase MAP to 75% of the baseline value (60–180 min). Sublingual carbon-dioxide partial pressure was measured by tonometry, using a specially coiled silicone rubber tube. Mucosal red blood cell velocity (RBCV) and capillary perfusion rate (CPR) were assessed by orthogonal polarization spectral (OPS) imaging. In the 60 min shock phase a significant drop in cardiac index was accompanied by reduction in sublingual RBCV and CPR and significant increase in the sublingual mucosal-to-arterial PCO(2) gap (P(SL)CO(2) gap), which significantly improved during the 120 min resuscitation phase. There was significant correlation between P(SL)CO(2) gap and sublingual RBCV (r = −0.65, p < 0.0001), CPR (r = −0.64, p < 0.0001), central venous oxygen saturation (r = −0.50, p < 0.0001), and central venous-to-arterial PCO(2) difference (r = 0.62, p < 0.0001). This new sublingual tonometer may be an appropriate tool for the indirect evaluation of circulatory changes in shock. Hindawi Publishing Corporation 2015 2015-10-04 /pmc/articles/PMC4609384/ /pubmed/26504837 http://dx.doi.org/10.1155/2015/847152 Text en Copyright © 2015 Péter Palágyi et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Palágyi, Péter Kaszaki, József Rostás, Andrea Érces, Dániel Németh, Márton Boros, Mihály Molnár, Zsolt Monitoring Microcirculatory Blood Flow with a New Sublingual Tonometer in a Porcine Model of Hemorrhagic Shock |
title | Monitoring Microcirculatory Blood Flow with a New Sublingual Tonometer in a Porcine Model of Hemorrhagic Shock |
title_full | Monitoring Microcirculatory Blood Flow with a New Sublingual Tonometer in a Porcine Model of Hemorrhagic Shock |
title_fullStr | Monitoring Microcirculatory Blood Flow with a New Sublingual Tonometer in a Porcine Model of Hemorrhagic Shock |
title_full_unstemmed | Monitoring Microcirculatory Blood Flow with a New Sublingual Tonometer in a Porcine Model of Hemorrhagic Shock |
title_short | Monitoring Microcirculatory Blood Flow with a New Sublingual Tonometer in a Porcine Model of Hemorrhagic Shock |
title_sort | monitoring microcirculatory blood flow with a new sublingual tonometer in a porcine model of hemorrhagic shock |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4609384/ https://www.ncbi.nlm.nih.gov/pubmed/26504837 http://dx.doi.org/10.1155/2015/847152 |
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