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Predictive Biomarkers to Chemoradiation in Locally Advanced Rectal Cancer
There has been a high local recurrence rate in rectal cancer. Besides improvements in surgical techniques, both neoadjuvant short-course radiotherapy and long-course chemoradiation improve oncological results. Approximately 40–60% of rectal cancer patients treated with neoadjuvant chemoradiation ach...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4609421/ https://www.ncbi.nlm.nih.gov/pubmed/26504848 http://dx.doi.org/10.1155/2015/921435 |
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author | Conde-Muíño, Raquel Cuadros, Marta Zambudio, Natalia Segura-Jiménez, Inmaculada Cano, Carlos Palma, Pablo |
author_facet | Conde-Muíño, Raquel Cuadros, Marta Zambudio, Natalia Segura-Jiménez, Inmaculada Cano, Carlos Palma, Pablo |
author_sort | Conde-Muíño, Raquel |
collection | PubMed |
description | There has been a high local recurrence rate in rectal cancer. Besides improvements in surgical techniques, both neoadjuvant short-course radiotherapy and long-course chemoradiation improve oncological results. Approximately 40–60% of rectal cancer patients treated with neoadjuvant chemoradiation achieve some degree of pathologic response. However, there is no effective method of predicting which patients will respond to neoadjuvant treatment. Recent studies have evaluated the potential of genetic biomarkers to predict outcome in locally advanced rectal adenocarcinoma treated with neoadjuvant chemoradiation. The articles produced by the PubMed search were reviewed for those specifically addressing a genetic profile's ability to predict response to neoadjuvant treatment in rectal cancer. Although tissue gene microarray profiling has led to promising data in cancer, to date, none of the identified signatures or molecular markers in locally advanced rectal cancer has been successfully validated as a diagnostic or prognostic tool applicable to routine clinical practice. |
format | Online Article Text |
id | pubmed-4609421 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-46094212015-10-26 Predictive Biomarkers to Chemoradiation in Locally Advanced Rectal Cancer Conde-Muíño, Raquel Cuadros, Marta Zambudio, Natalia Segura-Jiménez, Inmaculada Cano, Carlos Palma, Pablo Biomed Res Int Review Article There has been a high local recurrence rate in rectal cancer. Besides improvements in surgical techniques, both neoadjuvant short-course radiotherapy and long-course chemoradiation improve oncological results. Approximately 40–60% of rectal cancer patients treated with neoadjuvant chemoradiation achieve some degree of pathologic response. However, there is no effective method of predicting which patients will respond to neoadjuvant treatment. Recent studies have evaluated the potential of genetic biomarkers to predict outcome in locally advanced rectal adenocarcinoma treated with neoadjuvant chemoradiation. The articles produced by the PubMed search were reviewed for those specifically addressing a genetic profile's ability to predict response to neoadjuvant treatment in rectal cancer. Although tissue gene microarray profiling has led to promising data in cancer, to date, none of the identified signatures or molecular markers in locally advanced rectal cancer has been successfully validated as a diagnostic or prognostic tool applicable to routine clinical practice. Hindawi Publishing Corporation 2015 2015-10-04 /pmc/articles/PMC4609421/ /pubmed/26504848 http://dx.doi.org/10.1155/2015/921435 Text en Copyright © 2015 Raquel Conde-Muíño et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Conde-Muíño, Raquel Cuadros, Marta Zambudio, Natalia Segura-Jiménez, Inmaculada Cano, Carlos Palma, Pablo Predictive Biomarkers to Chemoradiation in Locally Advanced Rectal Cancer |
title | Predictive Biomarkers to Chemoradiation in Locally Advanced Rectal Cancer |
title_full | Predictive Biomarkers to Chemoradiation in Locally Advanced Rectal Cancer |
title_fullStr | Predictive Biomarkers to Chemoradiation in Locally Advanced Rectal Cancer |
title_full_unstemmed | Predictive Biomarkers to Chemoradiation in Locally Advanced Rectal Cancer |
title_short | Predictive Biomarkers to Chemoradiation in Locally Advanced Rectal Cancer |
title_sort | predictive biomarkers to chemoradiation in locally advanced rectal cancer |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4609421/ https://www.ncbi.nlm.nih.gov/pubmed/26504848 http://dx.doi.org/10.1155/2015/921435 |
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