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Liver Expression of Sulphotransferase 2A1 Enzyme Is Impaired in Patients with Primary Sclerosing Cholangitis: Lack of the Response to Enhanced Expression of PXR

Background/Aim. Sulphotransferase 2A1 (SULT2A1) exerts hepatoprotective effects. Transcription of SULT2A1 gene is induced by pregnane-X-receptor (PXR) and can be repressed by miR-378a-5p. We studied the PXR/SULT2A1 axis in chronic cholestatic conditions: primary sclerosing cholangitis (PSC) and prim...

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Detalles Bibliográficos
Autores principales:	Wunsch, Ewa, Klak, Marta, Wasik, Urszula, Milkiewicz, Malgorzata, Blatkiewicz, Malgorzata, Urasinska, Elzbieta, Barbier, Olivier, Bielicki, Dariusz, Bogdanos, Dimitrios P., Elias, Elwyn, Milkiewicz, Piotr
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4609469/ https://www.ncbi.nlm.nih.gov/pubmed/26504856 http://dx.doi.org/10.1155/2015/571353

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