Optimal Cutoff Titers for Indirect Immunofluorescence Assay for Diagnosis of Scrub Typhus

We determined the optimal cutoff titers in admission and convalescent-phase samples for scrub typhus indirect immunofluorescence assay using Bayesian latent class models. Cutoff titers of ≥1:3,200 in an admission sample or of a ≥4-fold rise to ≥1:3,200 in a convalescent-phase sample provided the hig...

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Detalles Bibliográficos
Autores principales: Lim, Cherry, Blacksell, Stuart D., Laongnualpanich, Achara, Kantipong, Pacharee, Day, Nicholas P. J., Paris, Daniel H., Limmathurotsakul, Direk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2015
Materias:
Chlamydiology and Rickettsiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4609688/
https://www.ncbi.nlm.nih.gov/pubmed/26354819
http://dx.doi.org/10.1128/JCM.01680-15
Descripción
Sumario:We determined the optimal cutoff titers in admission and convalescent-phase samples for scrub typhus indirect immunofluorescence assay using Bayesian latent class models. Cutoff titers of ≥1:3,200 in an admission sample or of a ≥4-fold rise to ≥1:3,200 in a convalescent-phase sample provided the highest accuracy (sensitivity, 81.6%; specificity, 100%).

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