Optimal Cutoff Titers for Indirect Immunofluorescence Assay for Diagnosis of Scrub Typhus

We determined the optimal cutoff titers in admission and convalescent-phase samples for scrub typhus indirect immunofluorescence assay using Bayesian latent class models. Cutoff titers of ≥1:3,200 in an admission sample or of a ≥4-fold rise to ≥1:3,200 in a convalescent-phase sample provided the hig...

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Autores principales: Lim, Cherry, Blacksell, Stuart D., Laongnualpanich, Achara, Kantipong, Pacharee, Day, Nicholas P. J., Paris, Daniel H., Limmathurotsakul, Direk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2015
Materias:
Chlamydiology and Rickettsiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4609688/
https://www.ncbi.nlm.nih.gov/pubmed/26354819
http://dx.doi.org/10.1128/JCM.01680-15
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author Lim, Cherry
Blacksell, Stuart D.
Laongnualpanich, Achara
Kantipong, Pacharee
Day, Nicholas P. J.
Paris, Daniel H.
Limmathurotsakul, Direk
author_facet Lim, Cherry
Blacksell, Stuart D.
Laongnualpanich, Achara
Kantipong, Pacharee
Day, Nicholas P. J.
Paris, Daniel H.
Limmathurotsakul, Direk
author_sort Lim, Cherry
collection PubMed
description We determined the optimal cutoff titers in admission and convalescent-phase samples for scrub typhus indirect immunofluorescence assay using Bayesian latent class models. Cutoff titers of ≥1:3,200 in an admission sample or of a ≥4-fold rise to ≥1:3,200 in a convalescent-phase sample provided the highest accuracy (sensitivity, 81.6%; specificity, 100%).
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spelling pubmed-46096882015-12-22 Optimal Cutoff Titers for Indirect Immunofluorescence Assay for Diagnosis of Scrub Typhus Lim, Cherry Blacksell, Stuart D. Laongnualpanich, Achara Kantipong, Pacharee Day, Nicholas P. J. Paris, Daniel H. Limmathurotsakul, Direk J Clin Microbiol Chlamydiology and Rickettsiology We determined the optimal cutoff titers in admission and convalescent-phase samples for scrub typhus indirect immunofluorescence assay using Bayesian latent class models. Cutoff titers of ≥1:3,200 in an admission sample or of a ≥4-fold rise to ≥1:3,200 in a convalescent-phase sample provided the highest accuracy (sensitivity, 81.6%; specificity, 100%). American Society for Microbiology 2015-10-16 2015-11 /pmc/articles/PMC4609688/ /pubmed/26354819 http://dx.doi.org/10.1128/JCM.01680-15 Text en Copyright © 2015, Lim et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 3.0 Unported license (http://creativecommons.org/licenses/by/3.0/) .
spellingShingle Chlamydiology and Rickettsiology
Lim, Cherry
Blacksell, Stuart D.
Laongnualpanich, Achara
Kantipong, Pacharee
Day, Nicholas P. J.
Paris, Daniel H.
Limmathurotsakul, Direk
Optimal Cutoff Titers for Indirect Immunofluorescence Assay for Diagnosis of Scrub Typhus
title Optimal Cutoff Titers for Indirect Immunofluorescence Assay for Diagnosis of Scrub Typhus
title_full Optimal Cutoff Titers for Indirect Immunofluorescence Assay for Diagnosis of Scrub Typhus
title_fullStr Optimal Cutoff Titers for Indirect Immunofluorescence Assay for Diagnosis of Scrub Typhus
title_full_unstemmed Optimal Cutoff Titers for Indirect Immunofluorescence Assay for Diagnosis of Scrub Typhus
title_short Optimal Cutoff Titers for Indirect Immunofluorescence Assay for Diagnosis of Scrub Typhus
title_sort optimal cutoff titers for indirect immunofluorescence assay for diagnosis of scrub typhus
topic Chlamydiology and Rickettsiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4609688/
https://www.ncbi.nlm.nih.gov/pubmed/26354819
http://dx.doi.org/10.1128/JCM.01680-15
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