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BRCA1 Is Required for Maintenance of Phospho-Chk1 and G(2)/M Arrest during DNA Cross-Link Repair in DT40 Cells
The Fanconi anemia DNA repair pathway is pivotal for the efficient repair of DNA interstrand cross-links. Here, we show that FA-defective (Fancc(−)) DT40 cells arrest in G(2) phase following cross-link damage and trigger apoptosis. Strikingly, cell death was reduced in Fancc(−) cells by additional d...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Microbiology
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4609749/ https://www.ncbi.nlm.nih.gov/pubmed/26324327 http://dx.doi.org/10.1128/MCB.01497-14 |