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Bone Regeneration from PLGA Micro-Nanoparticles

Poly-lactic-co-glycolic acid (PLGA) is one of the most widely used synthetic polymers for development of delivery systems for drugs and therapeutic biomolecules and as component of tissue engineering applications. Its properties and versatility allow it to be a reference polymer in manufacturing of...

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Autores principales: Ortega-Oller, Inmaculada, Padial-Molina, Miguel, Galindo-Moreno, Pablo, O'Valle, Francisco, Jódar-Reyes, Ana Belén, Peula-García, Jose Manuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4609778/
https://www.ncbi.nlm.nih.gov/pubmed/26509156
http://dx.doi.org/10.1155/2015/415289
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author Ortega-Oller, Inmaculada
Padial-Molina, Miguel
Galindo-Moreno, Pablo
O'Valle, Francisco
Jódar-Reyes, Ana Belén
Peula-García, Jose Manuel
author_facet Ortega-Oller, Inmaculada
Padial-Molina, Miguel
Galindo-Moreno, Pablo
O'Valle, Francisco
Jódar-Reyes, Ana Belén
Peula-García, Jose Manuel
author_sort Ortega-Oller, Inmaculada
collection PubMed
description Poly-lactic-co-glycolic acid (PLGA) is one of the most widely used synthetic polymers for development of delivery systems for drugs and therapeutic biomolecules and as component of tissue engineering applications. Its properties and versatility allow it to be a reference polymer in manufacturing of nano- and microparticles to encapsulate and deliver a wide variety of hydrophobic and hydrophilic molecules. It additionally facilitates and extends its use to encapsulate biomolecules such as proteins or nucleic acids that can be released in a controlled way. This review focuses on the use of nano/microparticles of PLGA as a delivery system of one of the most commonly used growth factors in bone tissue engineering, the bone morphogenetic protein 2 (BMP2). Thus, all the needed requirements to reach a controlled delivery of BMP2 using PLGA particles as a main component have been examined. The problems and solutions for the adequate development of this system with a great potential in cell differentiation and proliferation processes under a bone regenerative point of view are discussed.
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spelling pubmed-46097782015-10-27 Bone Regeneration from PLGA Micro-Nanoparticles Ortega-Oller, Inmaculada Padial-Molina, Miguel Galindo-Moreno, Pablo O'Valle, Francisco Jódar-Reyes, Ana Belén Peula-García, Jose Manuel Biomed Res Int Review Article Poly-lactic-co-glycolic acid (PLGA) is one of the most widely used synthetic polymers for development of delivery systems for drugs and therapeutic biomolecules and as component of tissue engineering applications. Its properties and versatility allow it to be a reference polymer in manufacturing of nano- and microparticles to encapsulate and deliver a wide variety of hydrophobic and hydrophilic molecules. It additionally facilitates and extends its use to encapsulate biomolecules such as proteins or nucleic acids that can be released in a controlled way. This review focuses on the use of nano/microparticles of PLGA as a delivery system of one of the most commonly used growth factors in bone tissue engineering, the bone morphogenetic protein 2 (BMP2). Thus, all the needed requirements to reach a controlled delivery of BMP2 using PLGA particles as a main component have been examined. The problems and solutions for the adequate development of this system with a great potential in cell differentiation and proliferation processes under a bone regenerative point of view are discussed. Hindawi Publishing Corporation 2015 2015-10-05 /pmc/articles/PMC4609778/ /pubmed/26509156 http://dx.doi.org/10.1155/2015/415289 Text en Copyright © 2015 Inmaculada Ortega-Oller et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Ortega-Oller, Inmaculada
Padial-Molina, Miguel
Galindo-Moreno, Pablo
O'Valle, Francisco
Jódar-Reyes, Ana Belén
Peula-García, Jose Manuel
Bone Regeneration from PLGA Micro-Nanoparticles
title Bone Regeneration from PLGA Micro-Nanoparticles
title_full Bone Regeneration from PLGA Micro-Nanoparticles
title_fullStr Bone Regeneration from PLGA Micro-Nanoparticles
title_full_unstemmed Bone Regeneration from PLGA Micro-Nanoparticles
title_short Bone Regeneration from PLGA Micro-Nanoparticles
title_sort bone regeneration from plga micro-nanoparticles
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4609778/
https://www.ncbi.nlm.nih.gov/pubmed/26509156
http://dx.doi.org/10.1155/2015/415289
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