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Molecular Characterization of Reactive Oxygen Species in Myocardial Ischemia-Reperfusion Injury
Myocardial ischemia-reperfusion (I/R) injury is experienced by individuals suffering from cardiovascular diseases such as coronary heart diseases and subsequently undergoing reperfusion treatments in order to manage the conditions. The occlusion of blood flow to the tissue, termed ischemia, can be e...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4609796/ https://www.ncbi.nlm.nih.gov/pubmed/26509170 http://dx.doi.org/10.1155/2015/864946 |
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author | Zhou, Tingyang Chuang, Chia-Chen Zuo, Li |
author_facet | Zhou, Tingyang Chuang, Chia-Chen Zuo, Li |
author_sort | Zhou, Tingyang |
collection | PubMed |
description | Myocardial ischemia-reperfusion (I/R) injury is experienced by individuals suffering from cardiovascular diseases such as coronary heart diseases and subsequently undergoing reperfusion treatments in order to manage the conditions. The occlusion of blood flow to the tissue, termed ischemia, can be especially detrimental to the heart due to its high energy demand. Several cellular alterations have been observed upon the onset of ischemia. The danger created by cardiac ischemia is somewhat paradoxical in that a return of blood to the tissue can result in further damage. Reactive oxygen species (ROS) have been studied intensively to reveal their role in myocardial I/R injury. Under normal conditions, ROS function as a mediator in many cell signaling pathways. However, stressful environments significantly induce the generation of ROS which causes the level to exceed body's antioxidant defense system. Such altered redox homeostasis is implicated in myocardial I/R injury. Despite the detrimental effects from ROS, low levels of ROS have been shown to exert a protective effect in the ischemic preconditioning. In this review, we will summarize the detrimental role of ROS in myocardial I/R injury, the protective mechanism induced by ROS, and potential treatments for ROS-related myocardial injury. |
format | Online Article Text |
id | pubmed-4609796 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-46097962015-10-27 Molecular Characterization of Reactive Oxygen Species in Myocardial Ischemia-Reperfusion Injury Zhou, Tingyang Chuang, Chia-Chen Zuo, Li Biomed Res Int Review Article Myocardial ischemia-reperfusion (I/R) injury is experienced by individuals suffering from cardiovascular diseases such as coronary heart diseases and subsequently undergoing reperfusion treatments in order to manage the conditions. The occlusion of blood flow to the tissue, termed ischemia, can be especially detrimental to the heart due to its high energy demand. Several cellular alterations have been observed upon the onset of ischemia. The danger created by cardiac ischemia is somewhat paradoxical in that a return of blood to the tissue can result in further damage. Reactive oxygen species (ROS) have been studied intensively to reveal their role in myocardial I/R injury. Under normal conditions, ROS function as a mediator in many cell signaling pathways. However, stressful environments significantly induce the generation of ROS which causes the level to exceed body's antioxidant defense system. Such altered redox homeostasis is implicated in myocardial I/R injury. Despite the detrimental effects from ROS, low levels of ROS have been shown to exert a protective effect in the ischemic preconditioning. In this review, we will summarize the detrimental role of ROS in myocardial I/R injury, the protective mechanism induced by ROS, and potential treatments for ROS-related myocardial injury. Hindawi Publishing Corporation 2015 2015-10-05 /pmc/articles/PMC4609796/ /pubmed/26509170 http://dx.doi.org/10.1155/2015/864946 Text en Copyright © 2015 Tingyang Zhou et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Zhou, Tingyang Chuang, Chia-Chen Zuo, Li Molecular Characterization of Reactive Oxygen Species in Myocardial Ischemia-Reperfusion Injury |
title | Molecular Characterization of Reactive Oxygen Species in Myocardial Ischemia-Reperfusion Injury |
title_full | Molecular Characterization of Reactive Oxygen Species in Myocardial Ischemia-Reperfusion Injury |
title_fullStr | Molecular Characterization of Reactive Oxygen Species in Myocardial Ischemia-Reperfusion Injury |
title_full_unstemmed | Molecular Characterization of Reactive Oxygen Species in Myocardial Ischemia-Reperfusion Injury |
title_short | Molecular Characterization of Reactive Oxygen Species in Myocardial Ischemia-Reperfusion Injury |
title_sort | molecular characterization of reactive oxygen species in myocardial ischemia-reperfusion injury |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4609796/ https://www.ncbi.nlm.nih.gov/pubmed/26509170 http://dx.doi.org/10.1155/2015/864946 |
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