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Molecular Characterization of Reactive Oxygen Species in Myocardial Ischemia-Reperfusion Injury

Myocardial ischemia-reperfusion (I/R) injury is experienced by individuals suffering from cardiovascular diseases such as coronary heart diseases and subsequently undergoing reperfusion treatments in order to manage the conditions. The occlusion of blood flow to the tissue, termed ischemia, can be e...

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Detalles Bibliográficos
Autores principales: Zhou, Tingyang, Chuang, Chia-Chen, Zuo, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4609796/
https://www.ncbi.nlm.nih.gov/pubmed/26509170
http://dx.doi.org/10.1155/2015/864946
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author Zhou, Tingyang
Chuang, Chia-Chen
Zuo, Li
author_facet Zhou, Tingyang
Chuang, Chia-Chen
Zuo, Li
author_sort Zhou, Tingyang
collection PubMed
description Myocardial ischemia-reperfusion (I/R) injury is experienced by individuals suffering from cardiovascular diseases such as coronary heart diseases and subsequently undergoing reperfusion treatments in order to manage the conditions. The occlusion of blood flow to the tissue, termed ischemia, can be especially detrimental to the heart due to its high energy demand. Several cellular alterations have been observed upon the onset of ischemia. The danger created by cardiac ischemia is somewhat paradoxical in that a return of blood to the tissue can result in further damage. Reactive oxygen species (ROS) have been studied intensively to reveal their role in myocardial I/R injury. Under normal conditions, ROS function as a mediator in many cell signaling pathways. However, stressful environments significantly induce the generation of ROS which causes the level to exceed body's antioxidant defense system. Such altered redox homeostasis is implicated in myocardial I/R injury. Despite the detrimental effects from ROS, low levels of ROS have been shown to exert a protective effect in the ischemic preconditioning. In this review, we will summarize the detrimental role of ROS in myocardial I/R injury, the protective mechanism induced by ROS, and potential treatments for ROS-related myocardial injury.
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spelling pubmed-46097962015-10-27 Molecular Characterization of Reactive Oxygen Species in Myocardial Ischemia-Reperfusion Injury Zhou, Tingyang Chuang, Chia-Chen Zuo, Li Biomed Res Int Review Article Myocardial ischemia-reperfusion (I/R) injury is experienced by individuals suffering from cardiovascular diseases such as coronary heart diseases and subsequently undergoing reperfusion treatments in order to manage the conditions. The occlusion of blood flow to the tissue, termed ischemia, can be especially detrimental to the heart due to its high energy demand. Several cellular alterations have been observed upon the onset of ischemia. The danger created by cardiac ischemia is somewhat paradoxical in that a return of blood to the tissue can result in further damage. Reactive oxygen species (ROS) have been studied intensively to reveal their role in myocardial I/R injury. Under normal conditions, ROS function as a mediator in many cell signaling pathways. However, stressful environments significantly induce the generation of ROS which causes the level to exceed body's antioxidant defense system. Such altered redox homeostasis is implicated in myocardial I/R injury. Despite the detrimental effects from ROS, low levels of ROS have been shown to exert a protective effect in the ischemic preconditioning. In this review, we will summarize the detrimental role of ROS in myocardial I/R injury, the protective mechanism induced by ROS, and potential treatments for ROS-related myocardial injury. Hindawi Publishing Corporation 2015 2015-10-05 /pmc/articles/PMC4609796/ /pubmed/26509170 http://dx.doi.org/10.1155/2015/864946 Text en Copyright © 2015 Tingyang Zhou et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Zhou, Tingyang
Chuang, Chia-Chen
Zuo, Li
Molecular Characterization of Reactive Oxygen Species in Myocardial Ischemia-Reperfusion Injury
title Molecular Characterization of Reactive Oxygen Species in Myocardial Ischemia-Reperfusion Injury
title_full Molecular Characterization of Reactive Oxygen Species in Myocardial Ischemia-Reperfusion Injury
title_fullStr Molecular Characterization of Reactive Oxygen Species in Myocardial Ischemia-Reperfusion Injury
title_full_unstemmed Molecular Characterization of Reactive Oxygen Species in Myocardial Ischemia-Reperfusion Injury
title_short Molecular Characterization of Reactive Oxygen Species in Myocardial Ischemia-Reperfusion Injury
title_sort molecular characterization of reactive oxygen species in myocardial ischemia-reperfusion injury
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4609796/
https://www.ncbi.nlm.nih.gov/pubmed/26509170
http://dx.doi.org/10.1155/2015/864946
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