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Effect of Rhizoma coptidis (Huang Lian) on Treating Diabetes Mellitus

The rapidly increasing diabetes mellitus (DM) is becoming a major public health issue globally; considerable progress has been made in the field of western hypoglycemic drug and insulin, but some shortages still exist. As one of the most important parts in complementary and alternative therapies, tr...

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Detalles Bibliográficos
Autores principales: Pang, Bing, Yu, Xiao-Tong, Zhou, Qiang, Zhao, Tian-Yu, Wang, Han, Gu, Cheng-Juan, Tong, Xiao-Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4609856/
https://www.ncbi.nlm.nih.gov/pubmed/26508987
http://dx.doi.org/10.1155/2015/921416
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author Pang, Bing
Yu, Xiao-Tong
Zhou, Qiang
Zhao, Tian-Yu
Wang, Han
Gu, Cheng-Juan
Tong, Xiao-Lin
author_facet Pang, Bing
Yu, Xiao-Tong
Zhou, Qiang
Zhao, Tian-Yu
Wang, Han
Gu, Cheng-Juan
Tong, Xiao-Lin
author_sort Pang, Bing
collection PubMed
description The rapidly increasing diabetes mellitus (DM) is becoming a major public health issue globally; considerable progress has been made in the field of western hypoglycemic drug and insulin, but some shortages still exist. As one of the most important parts in complementary and alternative therapies, traditional Chinese medicine (TCM) performs a good clinical practice and is showing a bright future in the treatment of DM. TCM therapy has certain advantages of less toxicity and/or side effects, and Chinese herbal medicine which usually contains various active ingredients could provide multiple therapeutic effects. Huang Lian (Rhizoma coptidis, RC) is a herb frequently used in many traditional formulas for properties of “clearing damp-heat, quenching fire, and counteracting poison” in Asia for centuries. In this review, we summarize the application of RC in the treatment of DM from two aspects of contents. Firstly, theoretical principles are explained, including the properties and related records about RC in ancient references and modern pharmacological researches and pharmacokinetics on RC and its active components. Secondly, the clinical application of RC is mainly reviewed, such as applicable stage and syndrome, the reasonable dose range, the preparation formulations, and the toxicity and/or side effects and solutions to its adverse actions. This review provides scientific evidence about the effective components, pharmacological researches, and toxicity of RC, as well as introducing traditional Chinese medical theory and clinical experience, in order to guide clinician to use RC more suitably and reasonably in the clinical practice.
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spelling pubmed-46098562015-10-27 Effect of Rhizoma coptidis (Huang Lian) on Treating Diabetes Mellitus Pang, Bing Yu, Xiao-Tong Zhou, Qiang Zhao, Tian-Yu Wang, Han Gu, Cheng-Juan Tong, Xiao-Lin Evid Based Complement Alternat Med Review Article The rapidly increasing diabetes mellitus (DM) is becoming a major public health issue globally; considerable progress has been made in the field of western hypoglycemic drug and insulin, but some shortages still exist. As one of the most important parts in complementary and alternative therapies, traditional Chinese medicine (TCM) performs a good clinical practice and is showing a bright future in the treatment of DM. TCM therapy has certain advantages of less toxicity and/or side effects, and Chinese herbal medicine which usually contains various active ingredients could provide multiple therapeutic effects. Huang Lian (Rhizoma coptidis, RC) is a herb frequently used in many traditional formulas for properties of “clearing damp-heat, quenching fire, and counteracting poison” in Asia for centuries. In this review, we summarize the application of RC in the treatment of DM from two aspects of contents. Firstly, theoretical principles are explained, including the properties and related records about RC in ancient references and modern pharmacological researches and pharmacokinetics on RC and its active components. Secondly, the clinical application of RC is mainly reviewed, such as applicable stage and syndrome, the reasonable dose range, the preparation formulations, and the toxicity and/or side effects and solutions to its adverse actions. This review provides scientific evidence about the effective components, pharmacological researches, and toxicity of RC, as well as introducing traditional Chinese medical theory and clinical experience, in order to guide clinician to use RC more suitably and reasonably in the clinical practice. Hindawi Publishing Corporation 2015 2015-10-05 /pmc/articles/PMC4609856/ /pubmed/26508987 http://dx.doi.org/10.1155/2015/921416 Text en Copyright © 2015 Bing Pang et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Pang, Bing
Yu, Xiao-Tong
Zhou, Qiang
Zhao, Tian-Yu
Wang, Han
Gu, Cheng-Juan
Tong, Xiao-Lin
Effect of Rhizoma coptidis (Huang Lian) on Treating Diabetes Mellitus
title Effect of Rhizoma coptidis (Huang Lian) on Treating Diabetes Mellitus
title_full Effect of Rhizoma coptidis (Huang Lian) on Treating Diabetes Mellitus
title_fullStr Effect of Rhizoma coptidis (Huang Lian) on Treating Diabetes Mellitus
title_full_unstemmed Effect of Rhizoma coptidis (Huang Lian) on Treating Diabetes Mellitus
title_short Effect of Rhizoma coptidis (Huang Lian) on Treating Diabetes Mellitus
title_sort effect of rhizoma coptidis (huang lian) on treating diabetes mellitus
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4609856/
https://www.ncbi.nlm.nih.gov/pubmed/26508987
http://dx.doi.org/10.1155/2015/921416
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