Human Mitochondrial DNA-Protein Complexes Attach to a Cholesterol-Rich Membrane Structure

The helicase Twinkle is indispensable for mtDNA replication in nucleoids. Previously, we showed that Twinkle is tightly membrane-associated even in the absence of mtDNA, which suggests that Twinkle is part of a membrane-attached replication platform. Here we show that this platform is a cholesterol-...

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Detalles Bibliográficos
Autores principales: Gerhold, Joachim M., Cansiz-Arda, Şirin, Lõhmus, Madis, Engberg, Oskar, Reyes, Aurelio, van Rennes, Helga, Sanz, Alberto, Holt, Ian J., Cooper, Helen M., Spelbrink, Johannes N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4609938/
https://www.ncbi.nlm.nih.gov/pubmed/26478270
http://dx.doi.org/10.1038/srep15292

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