Regulatory Elements in Vectors for Efficient Generation of Cell Lines Producing Target Proteins

To date, there has been an increasing number of drugs produced in mammalian cell cultures. In order to enhance the expression level and stability of target recombinant proteins in cell cultures, various regulatory elements with poorly studied mechanisms of action are used. In this review, we summari...

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Detalles Bibliográficos
Autores principales: Maksimenko, O., Gasanov, N. B., Georgiev, P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: A.I. Gordeyev 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610161/
https://www.ncbi.nlm.nih.gov/pubmed/26483956
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author Maksimenko, O.
Gasanov, N. B.
Georgiev, P.
author_facet Maksimenko, O.
Gasanov, N. B.
Georgiev, P.
author_sort Maksimenko, O.
collection PubMed
description To date, there has been an increasing number of drugs produced in mammalian cell cultures. In order to enhance the expression level and stability of target recombinant proteins in cell cultures, various regulatory elements with poorly studied mechanisms of action are used. In this review, we summarize and discuss the potential mechanisms of action of such regulatory elements.
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spelling pubmed-46101612015-10-19 Regulatory Elements in Vectors for Efficient Generation of Cell Lines Producing Target Proteins Maksimenko, O. Gasanov, N. B. Georgiev, P. Acta Naturae Research Article To date, there has been an increasing number of drugs produced in mammalian cell cultures. In order to enhance the expression level and stability of target recombinant proteins in cell cultures, various regulatory elements with poorly studied mechanisms of action are used. In this review, we summarize and discuss the potential mechanisms of action of such regulatory elements. A.I. Gordeyev 2015 /pmc/articles/PMC4610161/ /pubmed/26483956 Text en Copyright ® 2015 Park-media Ltd. http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Maksimenko, O.
Gasanov, N. B.
Georgiev, P.
Regulatory Elements in Vectors for Efficient Generation of Cell Lines Producing Target Proteins
title Regulatory Elements in Vectors for Efficient Generation of Cell Lines Producing Target Proteins
title_full Regulatory Elements in Vectors for Efficient Generation of Cell Lines Producing Target Proteins
title_fullStr Regulatory Elements in Vectors for Efficient Generation of Cell Lines Producing Target Proteins
title_full_unstemmed Regulatory Elements in Vectors for Efficient Generation of Cell Lines Producing Target Proteins
title_short Regulatory Elements in Vectors for Efficient Generation of Cell Lines Producing Target Proteins
title_sort regulatory elements in vectors for efficient generation of cell lines producing target proteins
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610161/
https://www.ncbi.nlm.nih.gov/pubmed/26483956
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