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Electrical Stimulation Elicits Neural Stem Cells Activation: New Perspectives in CNS Repair

Researchers are enthusiastically concerned about neural stem cell (NSC) therapy in a wide array of diseases, including stroke, neurodegenerative disease, spinal cord injury, and depression. Although enormous evidences have demonstrated that neurobehavioral improvement may benefit from NSC-supporting...

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Detalles Bibliográficos
Autores principales: Huang, Yanhua, Li, YeE, Chen, Jian, Zhou, Hongxing, Tan, Sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610200/
https://www.ncbi.nlm.nih.gov/pubmed/26539102
http://dx.doi.org/10.3389/fnhum.2015.00586
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author Huang, Yanhua
Li, YeE
Chen, Jian
Zhou, Hongxing
Tan, Sheng
author_facet Huang, Yanhua
Li, YeE
Chen, Jian
Zhou, Hongxing
Tan, Sheng
author_sort Huang, Yanhua
collection PubMed
description Researchers are enthusiastically concerned about neural stem cell (NSC) therapy in a wide array of diseases, including stroke, neurodegenerative disease, spinal cord injury, and depression. Although enormous evidences have demonstrated that neurobehavioral improvement may benefit from NSC-supporting regeneration in animal models, approaches to endogenous and transplanted NSCs are blocked by hurdles of migration, proliferation, maturation, and integration of NSCs. Electrical stimulation (ES) may be a selective non-drug approach for mobilizing NSCs in the central nervous system. This technique is suitable for clinical application, because it is well established and its potential complications are manageable. Here, we provide a comprehensive review of the emerging positive role of different electrical cues in regulating NSC biology in vitro and in vivo, as well as biomaterial-based and chemical stimulation of NSCs. In the future, ES combined with stem cell therapy or other cues probably becomes an approach for promoting brain repair.
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spelling pubmed-46102002015-11-04 Electrical Stimulation Elicits Neural Stem Cells Activation: New Perspectives in CNS Repair Huang, Yanhua Li, YeE Chen, Jian Zhou, Hongxing Tan, Sheng Front Hum Neurosci Neuroscience Researchers are enthusiastically concerned about neural stem cell (NSC) therapy in a wide array of diseases, including stroke, neurodegenerative disease, spinal cord injury, and depression. Although enormous evidences have demonstrated that neurobehavioral improvement may benefit from NSC-supporting regeneration in animal models, approaches to endogenous and transplanted NSCs are blocked by hurdles of migration, proliferation, maturation, and integration of NSCs. Electrical stimulation (ES) may be a selective non-drug approach for mobilizing NSCs in the central nervous system. This technique is suitable for clinical application, because it is well established and its potential complications are manageable. Here, we provide a comprehensive review of the emerging positive role of different electrical cues in regulating NSC biology in vitro and in vivo, as well as biomaterial-based and chemical stimulation of NSCs. In the future, ES combined with stem cell therapy or other cues probably becomes an approach for promoting brain repair. Frontiers Media S.A. 2015-10-19 /pmc/articles/PMC4610200/ /pubmed/26539102 http://dx.doi.org/10.3389/fnhum.2015.00586 Text en Copyright © 2015 Huang, Li, Chen, Zhou and Tan. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Huang, Yanhua
Li, YeE
Chen, Jian
Zhou, Hongxing
Tan, Sheng
Electrical Stimulation Elicits Neural Stem Cells Activation: New Perspectives in CNS Repair
title Electrical Stimulation Elicits Neural Stem Cells Activation: New Perspectives in CNS Repair
title_full Electrical Stimulation Elicits Neural Stem Cells Activation: New Perspectives in CNS Repair
title_fullStr Electrical Stimulation Elicits Neural Stem Cells Activation: New Perspectives in CNS Repair
title_full_unstemmed Electrical Stimulation Elicits Neural Stem Cells Activation: New Perspectives in CNS Repair
title_short Electrical Stimulation Elicits Neural Stem Cells Activation: New Perspectives in CNS Repair
title_sort electrical stimulation elicits neural stem cells activation: new perspectives in cns repair
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610200/
https://www.ncbi.nlm.nih.gov/pubmed/26539102
http://dx.doi.org/10.3389/fnhum.2015.00586
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