Impaired APP activity and altered Tau splicing in embryonic stem cell-derived astrocytes obtained from an APPsw transgenic minipig

Animal models of familial juvenile onset of Alzheimer's disease (AD) often fail to produce diverse pathological features of the disease by modification of single gene mutations that are responsible for the disease. They can hence be poor models for testing and development of novel drugs. Here,...

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Detalles Bibliográficos
Autores principales: Hall, Vanessa J., Lindblad, Maiken M., Jakobsen, Jannik E., Gunnarsson, Anders, Schmidt, Mette, Rasmussen, Mikkel A., Volke, Daniela, Zuchner, Thole, Hyttel, Poul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610230/
https://www.ncbi.nlm.nih.gov/pubmed/26398935
http://dx.doi.org/10.1242/dmm.019489

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