Palladium-Catalyzed α-Arylation of Aryl Acetic Acid Derivatives via Dienolate Intermediates with Aryl Chlorides and Bromides

[Image: see text] To date, examples of α-arylation of carboxylic acids remain scarce. Using a deprotonative cross-coupling process (DCCP), a method for palladium-catalyzed γ-arylation of aryl acetic acids with aryl halides has been developed. This protocol is applicable to a wide range of aryl bromi...

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Autores principales: Sha, Sheng-Chun, Zhang, Jiadi, Walsh, Patrick J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2015
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610326/
https://www.ncbi.nlm.nih.gov/pubmed/25582024
http://dx.doi.org/10.1021/ol503545j
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author Sha, Sheng-Chun
Zhang, Jiadi
Walsh, Patrick J.
author_facet Sha, Sheng-Chun
Zhang, Jiadi
Walsh, Patrick J.
author_sort Sha, Sheng-Chun
collection PubMed
description [Image: see text] To date, examples of α-arylation of carboxylic acids remain scarce. Using a deprotonative cross-coupling process (DCCP), a method for palladium-catalyzed γ-arylation of aryl acetic acids with aryl halides has been developed. This protocol is applicable to a wide range of aryl bromides and chlorides. A procedure for the palladium-catalyzed α-arylation of styryl acetic acids is also described.
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spelling pubmed-46103262016-01-12 Palladium-Catalyzed α-Arylation of Aryl Acetic Acid Derivatives via Dienolate Intermediates with Aryl Chlorides and Bromides Sha, Sheng-Chun Zhang, Jiadi Walsh, Patrick J. Org Lett [Image: see text] To date, examples of α-arylation of carboxylic acids remain scarce. Using a deprotonative cross-coupling process (DCCP), a method for palladium-catalyzed γ-arylation of aryl acetic acids with aryl halides has been developed. This protocol is applicable to a wide range of aryl bromides and chlorides. A procedure for the palladium-catalyzed α-arylation of styryl acetic acids is also described. American Chemical Society 2015-01-12 2015-02-06 /pmc/articles/PMC4610326/ /pubmed/25582024 http://dx.doi.org/10.1021/ol503545j Text en Copyright © 2015 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Sha, Sheng-Chun
Zhang, Jiadi
Walsh, Patrick J.
Palladium-Catalyzed α-Arylation of Aryl Acetic Acid Derivatives via Dienolate Intermediates with Aryl Chlorides and Bromides
title Palladium-Catalyzed α-Arylation of Aryl Acetic Acid Derivatives via Dienolate Intermediates with Aryl Chlorides and Bromides
title_full Palladium-Catalyzed α-Arylation of Aryl Acetic Acid Derivatives via Dienolate Intermediates with Aryl Chlorides and Bromides
title_fullStr Palladium-Catalyzed α-Arylation of Aryl Acetic Acid Derivatives via Dienolate Intermediates with Aryl Chlorides and Bromides
title_full_unstemmed Palladium-Catalyzed α-Arylation of Aryl Acetic Acid Derivatives via Dienolate Intermediates with Aryl Chlorides and Bromides
title_short Palladium-Catalyzed α-Arylation of Aryl Acetic Acid Derivatives via Dienolate Intermediates with Aryl Chlorides and Bromides
title_sort palladium-catalyzed α-arylation of aryl acetic acid derivatives via dienolate intermediates with aryl chlorides and bromides
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610326/
https://www.ncbi.nlm.nih.gov/pubmed/25582024
http://dx.doi.org/10.1021/ol503545j
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AT zhangjiadi palladiumcatalyzedaarylationofarylaceticacidderivativesviadienolateintermediateswitharylchloridesandbromides
AT walshpatrickj palladiumcatalyzedaarylationofarylaceticacidderivativesviadienolateintermediateswitharylchloridesandbromides

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