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A systematic review of the neural bases of psychotherapy for anxiety and related disorders

Brain imaging studies over two decades have delineated the neural circuitry of anxiety and related disorders, particularly regions involved in fear processing and in obsessive-compulsive symptoms. The neural circuitry of fear processing involves the amygdala, anterior cingulate, and insular cortex,...

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Detalles Bibliográficos
Autores principales: Brooks, Samantha J., Stein, Dan J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Les Laboratoires Servier 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610611/
https://www.ncbi.nlm.nih.gov/pubmed/26487807
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author Brooks, Samantha J.
Stein, Dan J.
author_facet Brooks, Samantha J.
Stein, Dan J.
author_sort Brooks, Samantha J.
collection PubMed
description Brain imaging studies over two decades have delineated the neural circuitry of anxiety and related disorders, particularly regions involved in fear processing and in obsessive-compulsive symptoms. The neural circuitry of fear processing involves the amygdala, anterior cingulate, and insular cortex, while cortico-striatal-thalamic circuitry plays a key role in obsessive-compulsive disorder. More recently, neuroimaging studies have examined how psychotherapy for anxiety and related disorders impacts on these neural circuits. Here we conduct a systematic review of the findings of such work, which yielded 19 functional magnetic resonance imaging studies examining the neural bases of cognitive-behavioral therapy (CBT) in 509 patients with anxiety and related disorders. We conclude that, although each of these related disorders is mediated by somewhat different neural circuitry, CBT may act in a similar way to increase prefrontal control of subcortical structures. These findings are consistent with an emphasis in cognitive-affective neuroscience on the potential therapeutic value of enhancing emotional regulation in various psychiatric conditions.
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spelling pubmed-46106112015-10-20 A systematic review of the neural bases of psychotherapy for anxiety and related disorders Brooks, Samantha J. Stein, Dan J. Dialogues Clin Neurosci Translational Research Brain imaging studies over two decades have delineated the neural circuitry of anxiety and related disorders, particularly regions involved in fear processing and in obsessive-compulsive symptoms. The neural circuitry of fear processing involves the amygdala, anterior cingulate, and insular cortex, while cortico-striatal-thalamic circuitry plays a key role in obsessive-compulsive disorder. More recently, neuroimaging studies have examined how psychotherapy for anxiety and related disorders impacts on these neural circuits. Here we conduct a systematic review of the findings of such work, which yielded 19 functional magnetic resonance imaging studies examining the neural bases of cognitive-behavioral therapy (CBT) in 509 patients with anxiety and related disorders. We conclude that, although each of these related disorders is mediated by somewhat different neural circuitry, CBT may act in a similar way to increase prefrontal control of subcortical structures. These findings are consistent with an emphasis in cognitive-affective neuroscience on the potential therapeutic value of enhancing emotional regulation in various psychiatric conditions. Les Laboratoires Servier 2015-09 /pmc/articles/PMC4610611/ /pubmed/26487807 Text en Copyright: © 2015 Institut la Conférence Hippocrate - Servier Research Group http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Translational Research
Brooks, Samantha J.
Stein, Dan J.
A systematic review of the neural bases of psychotherapy for anxiety and related disorders
title A systematic review of the neural bases of psychotherapy for anxiety and related disorders
title_full A systematic review of the neural bases of psychotherapy for anxiety and related disorders
title_fullStr A systematic review of the neural bases of psychotherapy for anxiety and related disorders
title_full_unstemmed A systematic review of the neural bases of psychotherapy for anxiety and related disorders
title_short A systematic review of the neural bases of psychotherapy for anxiety and related disorders
title_sort systematic review of the neural bases of psychotherapy for anxiety and related disorders
topic Translational Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610611/
https://www.ncbi.nlm.nih.gov/pubmed/26487807
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