Impact of the Tamsulosin in Alpha Adrenergic Receptor of Airways at Patients with Increased Bronchial Reactibility

OBJECTIVE: In this work, effect of tamsulosin as antagonist of alpha(1A) and alpha(1B) adrenergic receptor and effect of agonists of beta(2) adrenergic receptor–salbutamol in patients with increased bronchial reactibility was studied. METHODS: Parameters of the lung function are determined with Body plethysmography six (6) hours after administration of tamsulosin. Raw and ITGV were registered and specific resistance (SRaw) was calculated as well. Tamsulosin was administered in per os manner as a preparation in the shape of the capsules with a brand name of “Prolosin”, produced by Niche Generics Limited, Hitchin, Herts. RESULTS: After six (6) hours of administration of tamsulosin, results gained indicate that blockage of alpha(1A) and alpha(1B)-adrenergic receptor (0.8 mg per os) has not changed significantly (p > 0.1) the bronchomotor tonus of tracheobronchial tree in comparison to the check-up that has inhaled salbutamol agonist of adrenergic beta(2) receptor (2 inh. x 0.2 mg), (p < 0.05). Blood pressure suffered no significant decrease following administration of the 0.8 mg dose of tamsulosin. CONCLUSION: This suggests that even after six hours of administration of tamsulosin, and determining of lung function parameters, the activity of alpha(1A) and alpha(1B)-adrenergic receptor in the smooth bronchial musculature has not changed in patients with increased bronchial reactibility.