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Usefulness of Multi-Parametric MRI for the Investigation of Posterior Cortical Atrophy
BACKGROUND: Posterior Cortical Atrophy (PCA) is a neurodegenerative disease characterized by a progressive decline in selective cognitive functions anatomically referred to occipital, parietal and temporal brain regions, whose diagnosis is rather challenging for clinicians. The aim of this study was...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610670/ https://www.ncbi.nlm.nih.gov/pubmed/26480294 http://dx.doi.org/10.1371/journal.pone.0140639 |
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author | Arighi, Andrea Rango, Mario Bozzali, Marco Pietroboni, Anna M. Fumagalli, Giorgio Ghezzi, Laura Fenoglio, Chiara Biondetti, Pietro R. Bresolin, Nereo Galimberti, Daniela Scarpini, Elio |
author_facet | Arighi, Andrea Rango, Mario Bozzali, Marco Pietroboni, Anna M. Fumagalli, Giorgio Ghezzi, Laura Fenoglio, Chiara Biondetti, Pietro R. Bresolin, Nereo Galimberti, Daniela Scarpini, Elio |
author_sort | Arighi, Andrea |
collection | PubMed |
description | BACKGROUND: Posterior Cortical Atrophy (PCA) is a neurodegenerative disease characterized by a progressive decline in selective cognitive functions anatomically referred to occipital, parietal and temporal brain regions, whose diagnosis is rather challenging for clinicians. The aim of this study was to assess, using quantitative Magnetic Resonance Imaging techniques, the pattern of regional grey matter loss and metabolism in individuals with PCA to improve pathophysiological comprehension and diagnostic confidence. METHODS: We enrolled 5 patients with PCA and 5 matched controls who all underwent magnetic resonance imaging (MRI) and spectroscopy (MRS). Patients also underwent neuropsychological and cerebrospinal fluid (CSF) assessments. MRI data were used for unbiased assessment of regional grey matter loss in PCA patients compared to controls. MRS data were obtained from a set of brain regions, including the occipital lobe and the centrum semiovale bilaterally, and the posterior and anterior cingulate. RESULTS: VBM analysis documented the presence of focal brain atrophy in the occipital lobes and in the posterior parietal and temporal lobes bilaterally but more pronounced on the right hemisphere. MRS revealed, in the occipital lobes and in the posterior cingulate cortex of PCA patients, reduced levels of N-Acetyl Aspartate (NAA, a marker of neurodegeneration) and increased levels of Myo-Inositol (Ins, a glial marker), with no hemispheric lateralization. CONCLUSION: The bilateral but asymmetric pattern of regional grey matter loss is consistent with patients’ clinical and neuropsychological features and with previous literature. The MRS findings reveal different stages of neurodegeneration (neuronal loss; gliosis), which coexist and likely precede the occurrence of brain tissue loss, and might represent early biomarkers. In conclusion, this study indicates the potential usefulness of a multi-parametric MRI approach for an early diagnosis and staging of patients with PCA. |
format | Online Article Text |
id | pubmed-4610670 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-46106702015-10-29 Usefulness of Multi-Parametric MRI for the Investigation of Posterior Cortical Atrophy Arighi, Andrea Rango, Mario Bozzali, Marco Pietroboni, Anna M. Fumagalli, Giorgio Ghezzi, Laura Fenoglio, Chiara Biondetti, Pietro R. Bresolin, Nereo Galimberti, Daniela Scarpini, Elio PLoS One Research Article BACKGROUND: Posterior Cortical Atrophy (PCA) is a neurodegenerative disease characterized by a progressive decline in selective cognitive functions anatomically referred to occipital, parietal and temporal brain regions, whose diagnosis is rather challenging for clinicians. The aim of this study was to assess, using quantitative Magnetic Resonance Imaging techniques, the pattern of regional grey matter loss and metabolism in individuals with PCA to improve pathophysiological comprehension and diagnostic confidence. METHODS: We enrolled 5 patients with PCA and 5 matched controls who all underwent magnetic resonance imaging (MRI) and spectroscopy (MRS). Patients also underwent neuropsychological and cerebrospinal fluid (CSF) assessments. MRI data were used for unbiased assessment of regional grey matter loss in PCA patients compared to controls. MRS data were obtained from a set of brain regions, including the occipital lobe and the centrum semiovale bilaterally, and the posterior and anterior cingulate. RESULTS: VBM analysis documented the presence of focal brain atrophy in the occipital lobes and in the posterior parietal and temporal lobes bilaterally but more pronounced on the right hemisphere. MRS revealed, in the occipital lobes and in the posterior cingulate cortex of PCA patients, reduced levels of N-Acetyl Aspartate (NAA, a marker of neurodegeneration) and increased levels of Myo-Inositol (Ins, a glial marker), with no hemispheric lateralization. CONCLUSION: The bilateral but asymmetric pattern of regional grey matter loss is consistent with patients’ clinical and neuropsychological features and with previous literature. The MRS findings reveal different stages of neurodegeneration (neuronal loss; gliosis), which coexist and likely precede the occurrence of brain tissue loss, and might represent early biomarkers. In conclusion, this study indicates the potential usefulness of a multi-parametric MRI approach for an early diagnosis and staging of patients with PCA. Public Library of Science 2015-10-19 /pmc/articles/PMC4610670/ /pubmed/26480294 http://dx.doi.org/10.1371/journal.pone.0140639 Text en © 2015 Arighi et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Arighi, Andrea Rango, Mario Bozzali, Marco Pietroboni, Anna M. Fumagalli, Giorgio Ghezzi, Laura Fenoglio, Chiara Biondetti, Pietro R. Bresolin, Nereo Galimberti, Daniela Scarpini, Elio Usefulness of Multi-Parametric MRI for the Investigation of Posterior Cortical Atrophy |
title | Usefulness of Multi-Parametric MRI for the Investigation of Posterior Cortical Atrophy |
title_full | Usefulness of Multi-Parametric MRI for the Investigation of Posterior Cortical Atrophy |
title_fullStr | Usefulness of Multi-Parametric MRI for the Investigation of Posterior Cortical Atrophy |
title_full_unstemmed | Usefulness of Multi-Parametric MRI for the Investigation of Posterior Cortical Atrophy |
title_short | Usefulness of Multi-Parametric MRI for the Investigation of Posterior Cortical Atrophy |
title_sort | usefulness of multi-parametric mri for the investigation of posterior cortical atrophy |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610670/ https://www.ncbi.nlm.nih.gov/pubmed/26480294 http://dx.doi.org/10.1371/journal.pone.0140639 |
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