Design and evaluation of an intravesical delivery system for superficial bladder cancer: preparation of gemcitabine HCl-loaded chitosan–thioglycolic acid nanoparticles and comparison of chitosan/poloxamer gels as carriers

This study aimed to develop an intravesical delivery system of gemcitabine HCl for superficial bladder cancer in order to provide a controlled release profile, to prolong the residence time, and to avoid drug elimination via urination. For this aim, bioadhesive nanoparticles were prepared with thiol...

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Detalles Bibliográficos
Autores principales: Ay Şenyiğit, Zeynep, Karavana, Sinem Yaprak, İlem-Özdemir, Derya, Çalışkan, Çağrı, Waldner, Claudia, Şen, Sait, Bernkop-Schnürch, Andreas, Baloğlu, Esra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610785/
https://www.ncbi.nlm.nih.gov/pubmed/26508855
http://dx.doi.org/10.2147/IJN.S93750

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