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Development and evaluation of sunscreen creams containing morin-encapsulated nanoparticles for enhanced UV radiation protection and antioxidant activity

The objective of present work was to develop novel sunscreen creams containing polymeric nanoparticles (NPs) of morin. Polymeric NPs containing morin were prepared and optimized. The creams containing morin NPs were also prepared and evaluated. Optimized NPs exhibited particle size of 90.6 nm and ze...

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Autores principales: Shetty, Pallavi Krishna, Venuvanka, Venkatesh, Jagani, Hitesh Vitthal, Chethan, Gejjalagere Honnappa, Ligade, Virendra S, Musmade, Prashant B, Nayak, Usha Y, Reddy, Meka Sreenivasa, Kalthur, Guruprasad, Udupa, Nayanabhirama, Rao, Chamallamudi Mallikarjuna, Mutalik, Srinivas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610788/
https://www.ncbi.nlm.nih.gov/pubmed/26508854
http://dx.doi.org/10.2147/IJN.S90964
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author Shetty, Pallavi Krishna
Venuvanka, Venkatesh
Jagani, Hitesh Vitthal
Chethan, Gejjalagere Honnappa
Ligade, Virendra S
Musmade, Prashant B
Nayak, Usha Y
Reddy, Meka Sreenivasa
Kalthur, Guruprasad
Udupa, Nayanabhirama
Rao, Chamallamudi Mallikarjuna
Mutalik, Srinivas
author_facet Shetty, Pallavi Krishna
Venuvanka, Venkatesh
Jagani, Hitesh Vitthal
Chethan, Gejjalagere Honnappa
Ligade, Virendra S
Musmade, Prashant B
Nayak, Usha Y
Reddy, Meka Sreenivasa
Kalthur, Guruprasad
Udupa, Nayanabhirama
Rao, Chamallamudi Mallikarjuna
Mutalik, Srinivas
author_sort Shetty, Pallavi Krishna
collection PubMed
description The objective of present work was to develop novel sunscreen creams containing polymeric nanoparticles (NPs) of morin. Polymeric NPs containing morin were prepared and optimized. The creams containing morin NPs were also prepared and evaluated. Optimized NPs exhibited particle size of 90.6 nm and zeta potential of −31 mV. The entrapment efficiency of morin, within the polymeric NPs, was found to be low (12.27%). Fourier transformed infrared spectroscopy and differential scanning calorimetry studies revealed no interaction between morin and excipients. Transmission electron microscopy and atomic force microscopy revealed that the NPs were spherical in shape with approximately 100 nm diameter. Optimized NPs showed excellent in vitro free radical scavenging activity. Skin permeation and deposition of morin from its NPs was higher than its plain form. Different sunscreen creams (SC1–SC8) were formulated by incorporating morin NPs along with nano zinc oxide and nano titanium dioxide. SC5 and SC8 creams showed excellent sun protection factor values (≈40). In vitro and in vivo skin permeation studies of sunscreen creams containing morin NPs indicated excellent deposition of morin within the skin. Morin NPs and optimized cream formulations (SC5 and SC8) did not exhibit cytotoxicity in Vero and HaCaT cells. Optimized sunscreen creams showed excellent dermal safety. SC5 and SC8 creams demonstrated exceptional in vivo antioxidant effect (estimation of catalase, superoxide dismutase, and glutathione) in UV radiation-exposed rats. The optimized sunscreen creams confirmed outstanding UV radiation protection as well as antioxidant properties.
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spelling pubmed-46107882015-10-27 Development and evaluation of sunscreen creams containing morin-encapsulated nanoparticles for enhanced UV radiation protection and antioxidant activity Shetty, Pallavi Krishna Venuvanka, Venkatesh Jagani, Hitesh Vitthal Chethan, Gejjalagere Honnappa Ligade, Virendra S Musmade, Prashant B Nayak, Usha Y Reddy, Meka Sreenivasa Kalthur, Guruprasad Udupa, Nayanabhirama Rao, Chamallamudi Mallikarjuna Mutalik, Srinivas Int J Nanomedicine Original Research The objective of present work was to develop novel sunscreen creams containing polymeric nanoparticles (NPs) of morin. Polymeric NPs containing morin were prepared and optimized. The creams containing morin NPs were also prepared and evaluated. Optimized NPs exhibited particle size of 90.6 nm and zeta potential of −31 mV. The entrapment efficiency of morin, within the polymeric NPs, was found to be low (12.27%). Fourier transformed infrared spectroscopy and differential scanning calorimetry studies revealed no interaction between morin and excipients. Transmission electron microscopy and atomic force microscopy revealed that the NPs were spherical in shape with approximately 100 nm diameter. Optimized NPs showed excellent in vitro free radical scavenging activity. Skin permeation and deposition of morin from its NPs was higher than its plain form. Different sunscreen creams (SC1–SC8) were formulated by incorporating morin NPs along with nano zinc oxide and nano titanium dioxide. SC5 and SC8 creams showed excellent sun protection factor values (≈40). In vitro and in vivo skin permeation studies of sunscreen creams containing morin NPs indicated excellent deposition of morin within the skin. Morin NPs and optimized cream formulations (SC5 and SC8) did not exhibit cytotoxicity in Vero and HaCaT cells. Optimized sunscreen creams showed excellent dermal safety. SC5 and SC8 creams demonstrated exceptional in vivo antioxidant effect (estimation of catalase, superoxide dismutase, and glutathione) in UV radiation-exposed rats. The optimized sunscreen creams confirmed outstanding UV radiation protection as well as antioxidant properties. Dove Medical Press 2015-10-13 /pmc/articles/PMC4610788/ /pubmed/26508854 http://dx.doi.org/10.2147/IJN.S90964 Text en © 2015 Shetty et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Shetty, Pallavi Krishna
Venuvanka, Venkatesh
Jagani, Hitesh Vitthal
Chethan, Gejjalagere Honnappa
Ligade, Virendra S
Musmade, Prashant B
Nayak, Usha Y
Reddy, Meka Sreenivasa
Kalthur, Guruprasad
Udupa, Nayanabhirama
Rao, Chamallamudi Mallikarjuna
Mutalik, Srinivas
Development and evaluation of sunscreen creams containing morin-encapsulated nanoparticles for enhanced UV radiation protection and antioxidant activity
title Development and evaluation of sunscreen creams containing morin-encapsulated nanoparticles for enhanced UV radiation protection and antioxidant activity
title_full Development and evaluation of sunscreen creams containing morin-encapsulated nanoparticles for enhanced UV radiation protection and antioxidant activity
title_fullStr Development and evaluation of sunscreen creams containing morin-encapsulated nanoparticles for enhanced UV radiation protection and antioxidant activity
title_full_unstemmed Development and evaluation of sunscreen creams containing morin-encapsulated nanoparticles for enhanced UV radiation protection and antioxidant activity
title_short Development and evaluation of sunscreen creams containing morin-encapsulated nanoparticles for enhanced UV radiation protection and antioxidant activity
title_sort development and evaluation of sunscreen creams containing morin-encapsulated nanoparticles for enhanced uv radiation protection and antioxidant activity
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610788/
https://www.ncbi.nlm.nih.gov/pubmed/26508854
http://dx.doi.org/10.2147/IJN.S90964
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