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Design and activity of a cyclic mini-β-defensin analog: a novel antimicrobial tool

We have designed a cyclic 17-amino acid β-defensin analog featuring a single disulfide bond. This analog, designated “AMC” (ie, antimicrobial cyclic peptide), combines the internal hydrophobic domain of hBD1 and the C-terminal charged region of hBD3. The novel peptide was synthesized and characteriz...

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Detalles Bibliográficos
Autores principales:	Scudiero, Olga, Nigro, Ersilia, Cantisani, Marco, Colavita, Irene, Leone, Marilisa, Mercurio, Flavia Anna, Galdiero, Massimiliano, Pessi, Antonello, Daniele, Aurora, Salvatore, Francesco, Galdiero, Stefania
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2015
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610797/ https://www.ncbi.nlm.nih.gov/pubmed/26508857 http://dx.doi.org/10.2147/IJN.S89610

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