Cargando…
Spinal Gap Junction Channels in Neuropathic Pain
Damage to peripheral nerves or the spinal cord is often accompanied by neuropathic pain, which is a complex, chronic pain state. Increasing evidence indicates that alterations in the expression and activity of gap junction channels in the spinal cord are involved in the development of neuropathic pa...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Pain Society
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610936/ https://www.ncbi.nlm.nih.gov/pubmed/26495077 http://dx.doi.org/10.3344/kjp.2015.28.4.231 |
_version_ | 1782396015000682496 |
---|---|
author | Jeon, Young Hoon Youn, Dong Ho |
author_facet | Jeon, Young Hoon Youn, Dong Ho |
author_sort | Jeon, Young Hoon |
collection | PubMed |
description | Damage to peripheral nerves or the spinal cord is often accompanied by neuropathic pain, which is a complex, chronic pain state. Increasing evidence indicates that alterations in the expression and activity of gap junction channels in the spinal cord are involved in the development of neuropathic pain. Thus, this review briefly summarizes evidence that regulation of the expression, coupling, and activity of spinal gap junction channels modulates pain signals in neuropathic pain states induced by peripheral nerve or spinal cord injury. We particularly focus on connexin 43 and pannexin 1 because their regulation vastly attenuates symptoms of neuropathic pain. We hope that the study of gap junction channels eventually leads to the development of a suitable treatment tool for patients with neuropathic pain. |
format | Online Article Text |
id | pubmed-4610936 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | The Korean Pain Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-46109362015-10-22 Spinal Gap Junction Channels in Neuropathic Pain Jeon, Young Hoon Youn, Dong Ho Korean J Pain Review Article Damage to peripheral nerves or the spinal cord is often accompanied by neuropathic pain, which is a complex, chronic pain state. Increasing evidence indicates that alterations in the expression and activity of gap junction channels in the spinal cord are involved in the development of neuropathic pain. Thus, this review briefly summarizes evidence that regulation of the expression, coupling, and activity of spinal gap junction channels modulates pain signals in neuropathic pain states induced by peripheral nerve or spinal cord injury. We particularly focus on connexin 43 and pannexin 1 because their regulation vastly attenuates symptoms of neuropathic pain. We hope that the study of gap junction channels eventually leads to the development of a suitable treatment tool for patients with neuropathic pain. The Korean Pain Society 2015-10 2015-10-02 /pmc/articles/PMC4610936/ /pubmed/26495077 http://dx.doi.org/10.3344/kjp.2015.28.4.231 Text en Copyright © The Korean Pain Society, 2015 http://creativecommons.org/licenses/by-nc/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Jeon, Young Hoon Youn, Dong Ho Spinal Gap Junction Channels in Neuropathic Pain |
title | Spinal Gap Junction Channels in Neuropathic Pain |
title_full | Spinal Gap Junction Channels in Neuropathic Pain |
title_fullStr | Spinal Gap Junction Channels in Neuropathic Pain |
title_full_unstemmed | Spinal Gap Junction Channels in Neuropathic Pain |
title_short | Spinal Gap Junction Channels in Neuropathic Pain |
title_sort | spinal gap junction channels in neuropathic pain |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610936/ https://www.ncbi.nlm.nih.gov/pubmed/26495077 http://dx.doi.org/10.3344/kjp.2015.28.4.231 |
work_keys_str_mv | AT jeonyounghoon spinalgapjunctionchannelsinneuropathicpain AT youndongho spinalgapjunctionchannelsinneuropathicpain |