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Urinary nerve growth factor in patients with detrusor overactivity

BACKGROUND: Detrusor overactivity (DO) is one of the most frequent bladder dysfunctions in children up to the age of 18. Nowadays, the only way to confirm DO is by urodynamic investigation, which is an invasive procedure. Among the many mediators influencing bladder function, nerve growth factor (NG...

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Autores principales: Korzeniecka-Kozerska, A., Wasilewska, A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer London 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4611025/
https://www.ncbi.nlm.nih.gov/pubmed/24951086
http://dx.doi.org/10.1007/s11845-014-1162-8
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author Korzeniecka-Kozerska, A.
Wasilewska, A.
author_facet Korzeniecka-Kozerska, A.
Wasilewska, A.
author_sort Korzeniecka-Kozerska, A.
collection PubMed
description BACKGROUND: Detrusor overactivity (DO) is one of the most frequent bladder dysfunctions in children up to the age of 18. Nowadays, the only way to confirm DO is by urodynamic investigation, which is an invasive procedure. Among the many mediators influencing bladder function, nerve growth factor (NGF) plays an important role. The present study was designed to measure urinary NGF (uNGF) levels in patients with DO diagnosed by urodynamic study in comparison with healthy controls. METHODS: The investigation was conducted on 44 children, divided into two groups (24 patients with DO, 20 healthy children). Uroflowmetry was performed in all enrolled to the study and cystometry only to patients. uNGF levels were estimated in both studied groups. RESULTS: The median uNGF level in patients with DO before treatment was higher compared with healthy controls. There were no differences between uNGF levels in patients after anticholinergic treatment and the controls. We found differences in uroflowmetry parameters between the reference group and the patients. We found correlations between uroflowmetry parameters and uNGF/cr. level. CONCLUSIONS: 1. The uNGF level could be used for detecting DO in children and adolescents. 2. Measuring uNGF level is a simple, noninvasive procedure and very useful for choosing therapy in patients with DO in various clinical conditions.
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spelling pubmed-46110252015-10-22 Urinary nerve growth factor in patients with detrusor overactivity Korzeniecka-Kozerska, A. Wasilewska, A. Ir J Med Sci Original Article BACKGROUND: Detrusor overactivity (DO) is one of the most frequent bladder dysfunctions in children up to the age of 18. Nowadays, the only way to confirm DO is by urodynamic investigation, which is an invasive procedure. Among the many mediators influencing bladder function, nerve growth factor (NGF) plays an important role. The present study was designed to measure urinary NGF (uNGF) levels in patients with DO diagnosed by urodynamic study in comparison with healthy controls. METHODS: The investigation was conducted on 44 children, divided into two groups (24 patients with DO, 20 healthy children). Uroflowmetry was performed in all enrolled to the study and cystometry only to patients. uNGF levels were estimated in both studied groups. RESULTS: The median uNGF level in patients with DO before treatment was higher compared with healthy controls. There were no differences between uNGF levels in patients after anticholinergic treatment and the controls. We found differences in uroflowmetry parameters between the reference group and the patients. We found correlations between uroflowmetry parameters and uNGF/cr. level. CONCLUSIONS: 1. The uNGF level could be used for detecting DO in children and adolescents. 2. Measuring uNGF level is a simple, noninvasive procedure and very useful for choosing therapy in patients with DO in various clinical conditions. Springer London 2014-06-21 2015 /pmc/articles/PMC4611025/ /pubmed/24951086 http://dx.doi.org/10.1007/s11845-014-1162-8 Text en © The Author(s) 2014 https://creativecommons.org/licenses/by/4.0/ Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Original Article
Korzeniecka-Kozerska, A.
Wasilewska, A.
Urinary nerve growth factor in patients with detrusor overactivity
title Urinary nerve growth factor in patients with detrusor overactivity
title_full Urinary nerve growth factor in patients with detrusor overactivity
title_fullStr Urinary nerve growth factor in patients with detrusor overactivity
title_full_unstemmed Urinary nerve growth factor in patients with detrusor overactivity
title_short Urinary nerve growth factor in patients with detrusor overactivity
title_sort urinary nerve growth factor in patients with detrusor overactivity
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4611025/
https://www.ncbi.nlm.nih.gov/pubmed/24951086
http://dx.doi.org/10.1007/s11845-014-1162-8
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