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Pharmacological correction of excitation/inhibition imbalance in Down syndrome mouse models

Cognitive impairment in Down syndrome (DS) has been linked to increased synaptic inhibition. The underlying mechanisms remain unknown, but memory deficits are rescued in DS mouse models by drugs targeting GABA receptors. Similarly, administration of epigallocatechin gallate (EGCG)-containing extract...

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Detalles Bibliográficos
Autores principales:	Souchet, Benoit, Guedj, Fayçal, Penke-Verdier, Zsuza, Daubigney, Fabrice, Duchon, Arnaud, Herault, Yann, Bizot, Jean-Charles, Janel, Nathalie, Créau, Nicole, Delatour, Benoit, Delabar, Jean M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2015
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4611057/ https://www.ncbi.nlm.nih.gov/pubmed/26539088 http://dx.doi.org/10.3389/fnbeh.2015.00267

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