Identification of a Selective G1-Phase Benzimidazolone Inhibitor by a Senescence-Targeted Virtual Screen Using Artificial Neural Networks()()

Cellular senescence is a barrier to tumorigenesis in normal cells, and tumor cells undergo senescence responses to genotoxic stimuli, which is a potential target phenotype for cancer therapy. However, in this setting, mixed-mode responses are common with apoptosis the dominant effect. Hence, more se...

Descripción completa

Detalles Bibliográficos
Autores principales: Bilsland, Alan E., Pugliese, Angelo, Liu, Yu, Revie, John, Burns, Sharon, McCormick, Carol, Cairney, Claire J., Bower, Justin, Drysdale, Martin, Narita, Masashi, Sadaie, Mahito, Keith, W. Nicol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4611071/
https://www.ncbi.nlm.nih.gov/pubmed/26476078
http://dx.doi.org/10.1016/j.neo.2015.08.009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4611071/
https://www.ncbi.nlm.nih.gov/pubmed/26476078
http://dx.doi.org/10.1016/j.neo.2015.08.009

Ejemplares similares