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Pregnancy-related venous thrombosis: comparison between spontaneous and ART conception in an Italian cohort

OBJECTIVE: To evaluate in an Italian cohort the incidence of venous thromboembolic events (VTE) in pregnancies after assisted reproductive technologies (ART). SETTING: Thrombosis and Haemostasis Unit at I.R.C.C.S. ‘Casa Sollievo della Sofferenza’, S. Giovanni Rotondo. PARTICIPANTS: A prospective coh...

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Autores principales: Villani, Michela, Dentali, Francesco, Colaizzo, Donatella, Tiscia, Giovanni Luca, Vergura, Patrizia, Petruccelli, Tiziana, Petruzzelli, Francesco, Ageno, Walter, Margaglione, Maurizio, Grandone, Elvira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4611496/
https://www.ncbi.nlm.nih.gov/pubmed/26443651
http://dx.doi.org/10.1136/bmjopen-2015-008213
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author Villani, Michela
Dentali, Francesco
Colaizzo, Donatella
Tiscia, Giovanni Luca
Vergura, Patrizia
Petruccelli, Tiziana
Petruzzelli, Francesco
Ageno, Walter
Margaglione, Maurizio
Grandone, Elvira
author_facet Villani, Michela
Dentali, Francesco
Colaizzo, Donatella
Tiscia, Giovanni Luca
Vergura, Patrizia
Petruccelli, Tiziana
Petruzzelli, Francesco
Ageno, Walter
Margaglione, Maurizio
Grandone, Elvira
author_sort Villani, Michela
collection PubMed
description OBJECTIVE: To evaluate in an Italian cohort the incidence of venous thromboembolic events (VTE) in pregnancies after assisted reproductive technologies (ART). SETTING: Thrombosis and Haemostasis Unit at I.R.C.C.S. ‘Casa Sollievo della Sofferenza’, S. Giovanni Rotondo. PARTICIPANTS: A prospective cohort of 998 women advised to undergo ART was referred by local fertility clinics from April 2002 to July 2011. Follow-up information was obtained during the check-up and/or by phone interviews. In a cohort of women who consecutively gave birth (n=3339) after spontaneous conception in our Institution, information on the diagnoses of pregnancy-related venous thromboses was obtained by linkage to a patient administrative register. PRIMARY AND SECONDARY OUTCOME MEASURES: We calculated the incidence of VTE and superficial venous thrombosis in successful ART cycles and compared it with that of the general population conceiving spontaneously. RESULTS: Overall, 684 ART cycles were carried out by 234 women, who achieved a clinical pregnancy; in case of more than one successful cycle, only the first pregnancy was considered. Three vein thromboses (two VTE and one superficial vein thrombosis) were recorded. An antithrombotic prophylaxis with LMWH alone or combined with low-dose aspirin was prescribed in 23/234 (9.8%) women. In the reference cohort of 3339 women, a total of 11 vein thromboses were observed: six VTE and five SVT. The two-tailed Fisher exact test showed a trend towards statistical significance (p: 0.06, OR: 3.9, 95% CI 0.87 to 15.3). After the exclusion of superficial thromboses in both the groups, we found that the incidence of VTE in our population of women who had undergone ART was 2/234 pregnancies (8.5 ‰), whereas that in our reference population was 6/3339 (1.8 ‰) (p: 0.09). CONCLUSIONS: Our data show a slightly higher incidence of vein thromboses in pregnancies after ART than in those after natural conception.
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spelling pubmed-46114962015-10-23 Pregnancy-related venous thrombosis: comparison between spontaneous and ART conception in an Italian cohort Villani, Michela Dentali, Francesco Colaizzo, Donatella Tiscia, Giovanni Luca Vergura, Patrizia Petruccelli, Tiziana Petruzzelli, Francesco Ageno, Walter Margaglione, Maurizio Grandone, Elvira BMJ Open Reproductive Medicine OBJECTIVE: To evaluate in an Italian cohort the incidence of venous thromboembolic events (VTE) in pregnancies after assisted reproductive technologies (ART). SETTING: Thrombosis and Haemostasis Unit at I.R.C.C.S. ‘Casa Sollievo della Sofferenza’, S. Giovanni Rotondo. PARTICIPANTS: A prospective cohort of 998 women advised to undergo ART was referred by local fertility clinics from April 2002 to July 2011. Follow-up information was obtained during the check-up and/or by phone interviews. In a cohort of women who consecutively gave birth (n=3339) after spontaneous conception in our Institution, information on the diagnoses of pregnancy-related venous thromboses was obtained by linkage to a patient administrative register. PRIMARY AND SECONDARY OUTCOME MEASURES: We calculated the incidence of VTE and superficial venous thrombosis in successful ART cycles and compared it with that of the general population conceiving spontaneously. RESULTS: Overall, 684 ART cycles were carried out by 234 women, who achieved a clinical pregnancy; in case of more than one successful cycle, only the first pregnancy was considered. Three vein thromboses (two VTE and one superficial vein thrombosis) were recorded. An antithrombotic prophylaxis with LMWH alone or combined with low-dose aspirin was prescribed in 23/234 (9.8%) women. In the reference cohort of 3339 women, a total of 11 vein thromboses were observed: six VTE and five SVT. The two-tailed Fisher exact test showed a trend towards statistical significance (p: 0.06, OR: 3.9, 95% CI 0.87 to 15.3). After the exclusion of superficial thromboses in both the groups, we found that the incidence of VTE in our population of women who had undergone ART was 2/234 pregnancies (8.5 ‰), whereas that in our reference population was 6/3339 (1.8 ‰) (p: 0.09). CONCLUSIONS: Our data show a slightly higher incidence of vein thromboses in pregnancies after ART than in those after natural conception. BMJ Publishing Group 2015-10-05 /pmc/articles/PMC4611496/ /pubmed/26443651 http://dx.doi.org/10.1136/bmjopen-2015-008213 Text en Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
spellingShingle Reproductive Medicine
Villani, Michela
Dentali, Francesco
Colaizzo, Donatella
Tiscia, Giovanni Luca
Vergura, Patrizia
Petruccelli, Tiziana
Petruzzelli, Francesco
Ageno, Walter
Margaglione, Maurizio
Grandone, Elvira
Pregnancy-related venous thrombosis: comparison between spontaneous and ART conception in an Italian cohort
title Pregnancy-related venous thrombosis: comparison between spontaneous and ART conception in an Italian cohort
title_full Pregnancy-related venous thrombosis: comparison between spontaneous and ART conception in an Italian cohort
title_fullStr Pregnancy-related venous thrombosis: comparison between spontaneous and ART conception in an Italian cohort
title_full_unstemmed Pregnancy-related venous thrombosis: comparison between spontaneous and ART conception in an Italian cohort
title_short Pregnancy-related venous thrombosis: comparison between spontaneous and ART conception in an Italian cohort
title_sort pregnancy-related venous thrombosis: comparison between spontaneous and art conception in an italian cohort
topic Reproductive Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4611496/
https://www.ncbi.nlm.nih.gov/pubmed/26443651
http://dx.doi.org/10.1136/bmjopen-2015-008213
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