The B-Raf(V600E) inhibitor dabrafenib selectively inhibits RIP3 and alleviates acetaminophen-induced liver injury

Receptor-interacting protein (RIP)3 is a critical regulator of necroptosis and has been demonstrated to be associated with various diseases, suggesting that its inhibitors are promising in the clinic. However, there have been few RIP3 inhibitors reported as yet. B-Raf(V600E) inhibitors are an import...

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Detalles Bibliográficos
Autores principales: Li, J-X, Feng, J-M, Wang, Y, Li, X-H, Chen, X-X, Su, Y, Shen, Y-Y, Chen, Y, Xiong, B, Yang, C-H, Ding, J, Miao, Z-H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4611716/
https://www.ncbi.nlm.nih.gov/pubmed/24901049
http://dx.doi.org/10.1038/cddis.2014.241

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