Loss of function of the ALS protein SigR1 leads to ER pathology associated with defective autophagy and lipid raft disturbances

Intracellular accumulations of altered, misfolded proteins in neuronal and other cells are pathological hallmarks shared by many neurodegenerative diseases including amyotrophic lateral sclerosis (ALS). Mutations in several genes give rise to familial forms of ALS. Mutations in Sigma receptor 1 have...

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Detalles Bibliográficos
Autores principales: Vollrath, J T, Sechi, A, Dreser, A, Katona, I, Wiemuth, D, Vervoorts, J, Dohmen, M, Chandrasekar, A, Prause, J, Brauers, E, Jesse, C M, Weis, J, Goswami, A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4611717/
https://www.ncbi.nlm.nih.gov/pubmed/24922074
http://dx.doi.org/10.1038/cddis.2014.243

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