Validation of a chloroquine-induced cell death mechanism for clinical use against malaria

An alternative antimalarial pathway of an ‘outdated' drug, chloroquine (CQ), may facilitate its return to the shrinking list of effective antimalarials. Conventionally, CQ is believed to interfere with hemozoin formation at nanomolar concentrations, but resistant parasites are able to efflux th...

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Detalles Bibliográficos
Autores principales: Ch'ng, J-H, Lee, Y-Q, Gun, S Y, Chia, W-N, Chang, Z-W, Wong, L-K, Batty, K T, Russell, B, Nosten, F, Renia, L, Tan, K S-W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4611737/
https://www.ncbi.nlm.nih.gov/pubmed/24967967
http://dx.doi.org/10.1038/cddis.2014.265

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