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Pattern, etiological factors and determinants of mortality among sick newborns with seizures in Ilesa, Nigeria
BACKGROUND: Neonatal seizures contribute significantly to newborn morbidity and mortality particularly in developing countries including Nigeria. Unfortunately the countries with high incidence of neonatal seizures often lack the facilities to adequately diagnose, monitor and prognosticate the condi...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2015
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4611890/ https://www.ncbi.nlm.nih.gov/pubmed/26557162 http://dx.doi.org/10.4103/1817-1745.165663 |
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author | Kuti, Bankole Peter Oseni, Saheed Babajide Owa, Joshua Aderinsola |
author_facet | Kuti, Bankole Peter Oseni, Saheed Babajide Owa, Joshua Aderinsola |
author_sort | Kuti, Bankole Peter |
collection | PubMed |
description | BACKGROUND: Neonatal seizures contribute significantly to newborn morbidity and mortality particularly in developing countries including Nigeria. Unfortunately the countries with high incidence of neonatal seizures often lack the facilities to adequately diagnose, monitor and prognosticate the condition. OBJECTIVE: We set out to determine the factors at presentation that predict death among babies admitted with clinically identifiable seizures. METHODS: We prospectively observed consecutive neonatal admissions over a nine month period at the Wesley Guild Hospital, Ilesa, Nigeria. Babies with seizures were identified based on clinical observation. Perinatal history, examination and laboratory findings were compared between babies with seizures who survived and those that died. Multivariate regression analysis was used to determine the predictors of mortality. RESULTS: Over a nine month study period, a total of 340 babies were recruited out of which 55 (16.7 percent) had clinically identifiable seizures. Fifteen (27.3 percent) of the 55 babies with clinically identifiable seizures died; while 20 (7.0 percent) of the 285 babies without seizures died. Clinically identifiable neonatal seizures contributed to 42.9 percent of the overall mortality in the neonatal unit during the study period. The risk factors for mortality among the babies with seizures were clinical seizures in the first 24 hours of life, birth asphyxia co-existing with hyponatraemia and presence of cerebral oedema (P < 0.05). The independent determinant of mortality among babies with clinical seizures was cerebral oedema (OR = 4.025; 95% CI 1.342–26.956; P = 0.019). CONCLUSION: We conclude that clinically identifiable neonatal seizures contribute significantly to neonatal mortality and presentation within 24 hours of delivery, birth asphyxia and cerebral oedema increased the risk of death in babies with seizures. |
format | Online Article Text |
id | pubmed-4611890 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-46118902015-11-09 Pattern, etiological factors and determinants of mortality among sick newborns with seizures in Ilesa, Nigeria Kuti, Bankole Peter Oseni, Saheed Babajide Owa, Joshua Aderinsola J Pediatr Neurosci Original Article BACKGROUND: Neonatal seizures contribute significantly to newborn morbidity and mortality particularly in developing countries including Nigeria. Unfortunately the countries with high incidence of neonatal seizures often lack the facilities to adequately diagnose, monitor and prognosticate the condition. OBJECTIVE: We set out to determine the factors at presentation that predict death among babies admitted with clinically identifiable seizures. METHODS: We prospectively observed consecutive neonatal admissions over a nine month period at the Wesley Guild Hospital, Ilesa, Nigeria. Babies with seizures were identified based on clinical observation. Perinatal history, examination and laboratory findings were compared between babies with seizures who survived and those that died. Multivariate regression analysis was used to determine the predictors of mortality. RESULTS: Over a nine month study period, a total of 340 babies were recruited out of which 55 (16.7 percent) had clinically identifiable seizures. Fifteen (27.3 percent) of the 55 babies with clinically identifiable seizures died; while 20 (7.0 percent) of the 285 babies without seizures died. Clinically identifiable neonatal seizures contributed to 42.9 percent of the overall mortality in the neonatal unit during the study period. The risk factors for mortality among the babies with seizures were clinical seizures in the first 24 hours of life, birth asphyxia co-existing with hyponatraemia and presence of cerebral oedema (P < 0.05). The independent determinant of mortality among babies with clinical seizures was cerebral oedema (OR = 4.025; 95% CI 1.342–26.956; P = 0.019). CONCLUSION: We conclude that clinically identifiable neonatal seizures contribute significantly to neonatal mortality and presentation within 24 hours of delivery, birth asphyxia and cerebral oedema increased the risk of death in babies with seizures. Medknow Publications & Media Pvt Ltd 2015 /pmc/articles/PMC4611890/ /pubmed/26557162 http://dx.doi.org/10.4103/1817-1745.165663 Text en Copyright: © Journal of Pediatric Neurosciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution NonCommercial ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Kuti, Bankole Peter Oseni, Saheed Babajide Owa, Joshua Aderinsola Pattern, etiological factors and determinants of mortality among sick newborns with seizures in Ilesa, Nigeria |
title | Pattern, etiological factors and determinants of mortality among sick newborns with seizures in Ilesa, Nigeria |
title_full | Pattern, etiological factors and determinants of mortality among sick newborns with seizures in Ilesa, Nigeria |
title_fullStr | Pattern, etiological factors and determinants of mortality among sick newborns with seizures in Ilesa, Nigeria |
title_full_unstemmed | Pattern, etiological factors and determinants of mortality among sick newborns with seizures in Ilesa, Nigeria |
title_short | Pattern, etiological factors and determinants of mortality among sick newborns with seizures in Ilesa, Nigeria |
title_sort | pattern, etiological factors and determinants of mortality among sick newborns with seizures in ilesa, nigeria |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4611890/ https://www.ncbi.nlm.nih.gov/pubmed/26557162 http://dx.doi.org/10.4103/1817-1745.165663 |
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