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Habit-associated salivary pH changes in oral submucous fibrosis–A controlled cross-sectional study

CONTEXT: Oral submucous fibrosis (OSF) is a multi-causal inflammatory reaction to the chemical or mechanical trauma caused due to exposure to arecanut containing products with or without tobacco (ANCP/T). Arecanut and additional components such as lime and chewing tobacco render ANCP/T highly alkali...

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Autores principales: Donoghue, Mandana, Basandi, Praveen S, Adarsh, H, Madhushankari, GS, Selvamani, M, Nayak, Prachi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4611925/
https://www.ncbi.nlm.nih.gov/pubmed/26604493
http://dx.doi.org/10.4103/0973-029X.164529
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author Donoghue, Mandana
Basandi, Praveen S
Adarsh, H
Madhushankari, GS
Selvamani, M
Nayak, Prachi
author_facet Donoghue, Mandana
Basandi, Praveen S
Adarsh, H
Madhushankari, GS
Selvamani, M
Nayak, Prachi
author_sort Donoghue, Mandana
collection PubMed
description CONTEXT: Oral submucous fibrosis (OSF) is a multi-causal inflammatory reaction to the chemical or mechanical trauma caused due to exposure to arecanut containing products with or without tobacco (ANCP/T). Arecanut and additional components such as lime and chewing tobacco render ANCP/T highly alkaline. Fibrosing repair is a common reaction to an alkaline exposure in the skin. OSF may be related to the alkaline exposure by ANCP/T in a similar manner. AIMS: The study was aimed at establishing the relationship of habit-associated salivary pH changes and OSF. SETTINGS AND DESIGN: The study design was controlled cross-sectional. MATERIALS AND METHODS: Base line salivary pH (BLS pH), salivary pH after chewing the habitual ANCP/T substance, post chew salivary pH (PCSpH) for 2 min and salivary pH recovery time (SpHRT) were compared in 30 OSF patients and 30 sex-matched individuals with ANCP/T habits and apparently healthy oral mucosa. RESULTS: The group's mean BLSpH values were similar and within normal range and representative of the population level values. The average PCSpH was significantly higher (P ˂ 0.0001) than the average BLSpH in both groups. There was no significant difference (P = 0.09) between PCSpH of OSF patients and controls. OSF patients had a significantly longer (P = 0.0076) SpHRT than controls. Factors such as age, daily exposure, cumulative habit years, BLSpH and PCSpH, had varying effects on the groups. CONCLUSIONS: Chewing ANCP/T causes a significant rise in salivary pH of all individuals. SpHRT has a significant association with OSF. The effect of salivary changes in OSF patients differs with those in healthy controls.
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spelling pubmed-46119252015-11-24 Habit-associated salivary pH changes in oral submucous fibrosis–A controlled cross-sectional study Donoghue, Mandana Basandi, Praveen S Adarsh, H Madhushankari, GS Selvamani, M Nayak, Prachi J Oral Maxillofac Pathol Original Article CONTEXT: Oral submucous fibrosis (OSF) is a multi-causal inflammatory reaction to the chemical or mechanical trauma caused due to exposure to arecanut containing products with or without tobacco (ANCP/T). Arecanut and additional components such as lime and chewing tobacco render ANCP/T highly alkaline. Fibrosing repair is a common reaction to an alkaline exposure in the skin. OSF may be related to the alkaline exposure by ANCP/T in a similar manner. AIMS: The study was aimed at establishing the relationship of habit-associated salivary pH changes and OSF. SETTINGS AND DESIGN: The study design was controlled cross-sectional. MATERIALS AND METHODS: Base line salivary pH (BLS pH), salivary pH after chewing the habitual ANCP/T substance, post chew salivary pH (PCSpH) for 2 min and salivary pH recovery time (SpHRT) were compared in 30 OSF patients and 30 sex-matched individuals with ANCP/T habits and apparently healthy oral mucosa. RESULTS: The group's mean BLSpH values were similar and within normal range and representative of the population level values. The average PCSpH was significantly higher (P ˂ 0.0001) than the average BLSpH in both groups. There was no significant difference (P = 0.09) between PCSpH of OSF patients and controls. OSF patients had a significantly longer (P = 0.0076) SpHRT than controls. Factors such as age, daily exposure, cumulative habit years, BLSpH and PCSpH, had varying effects on the groups. CONCLUSIONS: Chewing ANCP/T causes a significant rise in salivary pH of all individuals. SpHRT has a significant association with OSF. The effect of salivary changes in OSF patients differs with those in healthy controls. Medknow Publications & Media Pvt Ltd 2015 /pmc/articles/PMC4611925/ /pubmed/26604493 http://dx.doi.org/10.4103/0973-029X.164529 Text en Copyright: © Journal of Oral and Maxillofacial Pathology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms
spellingShingle Original Article
Donoghue, Mandana
Basandi, Praveen S
Adarsh, H
Madhushankari, GS
Selvamani, M
Nayak, Prachi
Habit-associated salivary pH changes in oral submucous fibrosis–A controlled cross-sectional study
title Habit-associated salivary pH changes in oral submucous fibrosis–A controlled cross-sectional study
title_full Habit-associated salivary pH changes in oral submucous fibrosis–A controlled cross-sectional study
title_fullStr Habit-associated salivary pH changes in oral submucous fibrosis–A controlled cross-sectional study
title_full_unstemmed Habit-associated salivary pH changes in oral submucous fibrosis–A controlled cross-sectional study
title_short Habit-associated salivary pH changes in oral submucous fibrosis–A controlled cross-sectional study
title_sort habit-associated salivary ph changes in oral submucous fibrosis–a controlled cross-sectional study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4611925/
https://www.ncbi.nlm.nih.gov/pubmed/26604493
http://dx.doi.org/10.4103/0973-029X.164529
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