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Previous miscarriage and the subsequent risk of preterm birth in Scotland, 1980–2008: a historical cohort study

OBJECTIVE: To determine whether the relationship between previous miscarriage and risk of preterm birth changed over the period 1980–2008, and to determine whether the pattern varied according to the cause of the preterm birth. DESIGN: Linked birth databases. SETTING: All Scottish NHS hospitals. POP...

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Autores principales: Oliver-Williams, C, Fleming, M, Wood, AM, Smith, GCS
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4611958/
https://www.ncbi.nlm.nih.gov/pubmed/25626593
http://dx.doi.org/10.1111/1471-0528.13276
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author Oliver-Williams, C
Fleming, M
Wood, AM
Smith, GCS
author_facet Oliver-Williams, C
Fleming, M
Wood, AM
Smith, GCS
author_sort Oliver-Williams, C
collection PubMed
description OBJECTIVE: To determine whether the relationship between previous miscarriage and risk of preterm birth changed over the period 1980–2008, and to determine whether the pattern varied according to the cause of the preterm birth. DESIGN: Linked birth databases. SETTING: All Scottish NHS hospitals. POPULATION: A total of 732 719 nulliparous women with a first live birth between 1980 and 2008. METHODS: Risk was estimated using logistic regression. MAIN OUTCOME MEASURES: Preterm birth, subdivided by cause (spontaneous, induced with a diagnosis of pre-eclampsia, or induced without a diagnosis of pre-eclampsia) and severity [extreme (24–28 weeks of gestation), moderate (29–32 weeks of gestation), and mild (33–36 weeks of gestation)]. RESULTS: Consistent with previous studies, previous miscarriage was associated with an increased risk of all-cause preterm birth (adjusted odds ratio, aOR 1.26; 95% confidence interval, 95% CI 1.22–1.29). This arose from associations with all subtypes. The strongest association was found with extreme preterm birth (aOR 1.73; 95% CI 1.57–1.90). Risk increased with the number of miscarriages. Women with three or more miscarriages had the greatest risk of all-cause preterm birth (aOR 2.14; 95% CI 1.93–2.38), and the strongest association was with extreme preterm birth (aOR 3.87; 95% CI 2.85–5.26). The strength of the association between miscarriage and preterm birth decreased from 1980 to 2008. This was because of weakening associations with spontaneous preterm birth and induced preterm birth without a diagnosis of pre-eclampsia. CONCLUSIONS: The association between a prior history of miscarriage and the risk of preterm birth declined in Scotland over the period 1980–2008. We speculate that changes in the methods of managing incomplete termination of pregnancy might explain the trend, through reduced cervical damage.
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spelling pubmed-46119582015-10-26 Previous miscarriage and the subsequent risk of preterm birth in Scotland, 1980–2008: a historical cohort study Oliver-Williams, C Fleming, M Wood, AM Smith, GCS BJOG General Gynaecology OBJECTIVE: To determine whether the relationship between previous miscarriage and risk of preterm birth changed over the period 1980–2008, and to determine whether the pattern varied according to the cause of the preterm birth. DESIGN: Linked birth databases. SETTING: All Scottish NHS hospitals. POPULATION: A total of 732 719 nulliparous women with a first live birth between 1980 and 2008. METHODS: Risk was estimated using logistic regression. MAIN OUTCOME MEASURES: Preterm birth, subdivided by cause (spontaneous, induced with a diagnosis of pre-eclampsia, or induced without a diagnosis of pre-eclampsia) and severity [extreme (24–28 weeks of gestation), moderate (29–32 weeks of gestation), and mild (33–36 weeks of gestation)]. RESULTS: Consistent with previous studies, previous miscarriage was associated with an increased risk of all-cause preterm birth (adjusted odds ratio, aOR 1.26; 95% confidence interval, 95% CI 1.22–1.29). This arose from associations with all subtypes. The strongest association was found with extreme preterm birth (aOR 1.73; 95% CI 1.57–1.90). Risk increased with the number of miscarriages. Women with three or more miscarriages had the greatest risk of all-cause preterm birth (aOR 2.14; 95% CI 1.93–2.38), and the strongest association was with extreme preterm birth (aOR 3.87; 95% CI 2.85–5.26). The strength of the association between miscarriage and preterm birth decreased from 1980 to 2008. This was because of weakening associations with spontaneous preterm birth and induced preterm birth without a diagnosis of pre-eclampsia. CONCLUSIONS: The association between a prior history of miscarriage and the risk of preterm birth declined in Scotland over the period 1980–2008. We speculate that changes in the methods of managing incomplete termination of pregnancy might explain the trend, through reduced cervical damage. John Wiley & Sons, Ltd 2015-10 2015-01-28 /pmc/articles/PMC4611958/ /pubmed/25626593 http://dx.doi.org/10.1111/1471-0528.13276 Text en © 2015 The Authors. BJOG An International Journal of Obstetrics and Gynaecology published by John Wiley & Sons Ltd on behalf of Royal College of Obstetricians and Gynaecologists. http://creativecommons.org/licenses/by/4.0/ This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle General Gynaecology
Oliver-Williams, C
Fleming, M
Wood, AM
Smith, GCS
Previous miscarriage and the subsequent risk of preterm birth in Scotland, 1980–2008: a historical cohort study
title Previous miscarriage and the subsequent risk of preterm birth in Scotland, 1980–2008: a historical cohort study
title_full Previous miscarriage and the subsequent risk of preterm birth in Scotland, 1980–2008: a historical cohort study
title_fullStr Previous miscarriage and the subsequent risk of preterm birth in Scotland, 1980–2008: a historical cohort study
title_full_unstemmed Previous miscarriage and the subsequent risk of preterm birth in Scotland, 1980–2008: a historical cohort study
title_short Previous miscarriage and the subsequent risk of preterm birth in Scotland, 1980–2008: a historical cohort study
title_sort previous miscarriage and the subsequent risk of preterm birth in scotland, 1980–2008: a historical cohort study
topic General Gynaecology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4611958/
https://www.ncbi.nlm.nih.gov/pubmed/25626593
http://dx.doi.org/10.1111/1471-0528.13276
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