Combining silver- and organocatalysis: an enantioselective sequential catalytic approach towards pyrano-annulated pyrazoles

A one-pot asymmetric Michael addition/hydroalkoxylation sequence, catalyzed by a sequential catalytic system consisting of a squaramide and a silver salt, provides a new series of chiral pyrano-annulated pyrazole derivatives in excellent yields (up to 95%) and high enantioselectivities (up to 97% ee...

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Autores principales: Hack, Daniel, Chauhan, Pankaj, Deckers, Kristina, Mizutani, Yusuke, Raabe, Gerhard, Enders, Dieter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2015
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4611987/
https://www.ncbi.nlm.nih.gov/pubmed/25564304
http://dx.doi.org/10.1039/c4cc09495f
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author Hack, Daniel
Chauhan, Pankaj
Deckers, Kristina
Mizutani, Yusuke
Raabe, Gerhard
Enders, Dieter
author_facet Hack, Daniel
Chauhan, Pankaj
Deckers, Kristina
Mizutani, Yusuke
Raabe, Gerhard
Enders, Dieter
author_sort Hack, Daniel
collection PubMed
description A one-pot asymmetric Michael addition/hydroalkoxylation sequence, catalyzed by a sequential catalytic system consisting of a squaramide and a silver salt, provides a new series of chiral pyrano-annulated pyrazole derivatives in excellent yields (up to 95%) and high enantioselectivities (up to 97% ee).
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spelling pubmed-46119872015-11-23 Combining silver- and organocatalysis: an enantioselective sequential catalytic approach towards pyrano-annulated pyrazoles Hack, Daniel Chauhan, Pankaj Deckers, Kristina Mizutani, Yusuke Raabe, Gerhard Enders, Dieter Chem Commun (Camb) Chemistry A one-pot asymmetric Michael addition/hydroalkoxylation sequence, catalyzed by a sequential catalytic system consisting of a squaramide and a silver salt, provides a new series of chiral pyrano-annulated pyrazole derivatives in excellent yields (up to 95%) and high enantioselectivities (up to 97% ee). Royal Society of Chemistry 2015-01-27 2015-02-11 /pmc/articles/PMC4611987/ /pubmed/25564304 http://dx.doi.org/10.1039/c4cc09495f Text en This journal is © The Royal Society of Chemistry 2015 http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution 3.0 Unported License (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Chemistry
Hack, Daniel
Chauhan, Pankaj
Deckers, Kristina
Mizutani, Yusuke
Raabe, Gerhard
Enders, Dieter
Combining silver- and organocatalysis: an enantioselective sequential catalytic approach towards pyrano-annulated pyrazoles
title Combining silver- and organocatalysis: an enantioselective sequential catalytic approach towards pyrano-annulated pyrazoles
title_full Combining silver- and organocatalysis: an enantioselective sequential catalytic approach towards pyrano-annulated pyrazoles
title_fullStr Combining silver- and organocatalysis: an enantioselective sequential catalytic approach towards pyrano-annulated pyrazoles
title_full_unstemmed Combining silver- and organocatalysis: an enantioselective sequential catalytic approach towards pyrano-annulated pyrazoles
title_short Combining silver- and organocatalysis: an enantioselective sequential catalytic approach towards pyrano-annulated pyrazoles
title_sort combining silver- and organocatalysis: an enantioselective sequential catalytic approach towards pyrano-annulated pyrazoles
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4611987/
https://www.ncbi.nlm.nih.gov/pubmed/25564304
http://dx.doi.org/10.1039/c4cc09495f
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