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Collapse of the native structure caused by a single amino acid exchange in human NAD(P)H:quinone oxidoreductase

Human NAD(P)H:quinone oxidoreductase 1 (NQO1) is essential for the antioxidant defense system, stabilization of tumor suppressors (e.g. p53, p33, and p73), and activation of quinone-based chemotherapeutics. Overexpression of NQO1 in many solid tumors, coupled with its ability to convert quinone-base...

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Detalles Bibliográficos
Autores principales:	Lienhart, Wolf-Dieter, Gudipati, Venugopal, Uhl, Michael K., Binter, Alexandra, Pulido, Sergio A., Saf, Robert, Zangger, Klaus, Gruber, Karl, Macheroux, Peter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4612375/ https://www.ncbi.nlm.nih.gov/pubmed/25143260 http://dx.doi.org/10.1111/febs.12975

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