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Prevalence of inflammatory bowel disease among coeliac disease patients in a Hungarian coeliac centre

BACKGROUND: Celiac disease, Crohn disease and ulcerative colitis are inflammatory disorders of the gastrointestinal tract with some common genetic, immunological and environmental factors involved in their pathogenesis. Several research shown that patients with celiac disease have increased risk of...

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Autores principales: Kocsis, Dorottya, Tóth, Zsuzsanna, Csontos, Ágnes A., Miheller, Pál, Pák, Péter, Herszényi, László, Tóth, Miklós, Tulassay, Zsolt, Juhász, Márk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4612406/
https://www.ncbi.nlm.nih.gov/pubmed/26481725
http://dx.doi.org/10.1186/s12876-015-0370-7
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author Kocsis, Dorottya
Tóth, Zsuzsanna
Csontos, Ágnes A.
Miheller, Pál
Pák, Péter
Herszényi, László
Tóth, Miklós
Tulassay, Zsolt
Juhász, Márk
author_facet Kocsis, Dorottya
Tóth, Zsuzsanna
Csontos, Ágnes A.
Miheller, Pál
Pák, Péter
Herszényi, László
Tóth, Miklós
Tulassay, Zsolt
Juhász, Márk
author_sort Kocsis, Dorottya
collection PubMed
description BACKGROUND: Celiac disease, Crohn disease and ulcerative colitis are inflammatory disorders of the gastrointestinal tract with some common genetic, immunological and environmental factors involved in their pathogenesis. Several research shown that patients with celiac disease have increased risk of developing inflammatory bowel disease when compared with that of the general population. The aim of this study is to determine the prevalence of inflammatory bowel disease in our celiac patient cohort over a 15-year-long study period. METHODS: To diagnose celiac disease, serological tests were used, and duodenal biopsy samples were taken to determine the degree of mucosal injury. To set up the diagnosis of inflammatory bowel disease, clinical parameters, imaging techniques, colonoscopy histology were applied. DEXA for measuring bone mineral density was performed on every patient. RESULTS: In our material, 8/245 (3,2 %) coeliac disease patients presented inflammatory bowel disease (four males, mean age 37, range 22–67), 6/8 Crohn’s disease, and 2/8 ulcerative colitis. In 7/8 patients the diagnosis of coeliac disease was made first and inflammatory bowel disease was identified during follow-up. The average time period during the set-up of the two diagnosis was 10,7 years. Coeliac disease serology was positive in all cases. The distribution of histology results according to Marsh classification: 1/8 M1, 2/8 M2, 3/8 M3a, 2/8 M3b. The distribution according to the Montreal classification: 4/6 Crohn’s disease patients are B1, 2/6 Crohn’s disease patients are B2, 2/2 ulcerative colitis patients are S2. Normal bone mineral density was detected in 2/8 case, osteopenia in 4/8 and osteoporosis in 2/8 patients. CONCLUSIONS: Within our cohort of patients with coeliac disease, inflammatory bowel disease was significantly more common (3,2 %) than in the general population.
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spelling pubmed-46124062015-10-22 Prevalence of inflammatory bowel disease among coeliac disease patients in a Hungarian coeliac centre Kocsis, Dorottya Tóth, Zsuzsanna Csontos, Ágnes A. Miheller, Pál Pák, Péter Herszényi, László Tóth, Miklós Tulassay, Zsolt Juhász, Márk BMC Gastroenterol Research Article BACKGROUND: Celiac disease, Crohn disease and ulcerative colitis are inflammatory disorders of the gastrointestinal tract with some common genetic, immunological and environmental factors involved in their pathogenesis. Several research shown that patients with celiac disease have increased risk of developing inflammatory bowel disease when compared with that of the general population. The aim of this study is to determine the prevalence of inflammatory bowel disease in our celiac patient cohort over a 15-year-long study period. METHODS: To diagnose celiac disease, serological tests were used, and duodenal biopsy samples were taken to determine the degree of mucosal injury. To set up the diagnosis of inflammatory bowel disease, clinical parameters, imaging techniques, colonoscopy histology were applied. DEXA for measuring bone mineral density was performed on every patient. RESULTS: In our material, 8/245 (3,2 %) coeliac disease patients presented inflammatory bowel disease (four males, mean age 37, range 22–67), 6/8 Crohn’s disease, and 2/8 ulcerative colitis. In 7/8 patients the diagnosis of coeliac disease was made first and inflammatory bowel disease was identified during follow-up. The average time period during the set-up of the two diagnosis was 10,7 years. Coeliac disease serology was positive in all cases. The distribution of histology results according to Marsh classification: 1/8 M1, 2/8 M2, 3/8 M3a, 2/8 M3b. The distribution according to the Montreal classification: 4/6 Crohn’s disease patients are B1, 2/6 Crohn’s disease patients are B2, 2/2 ulcerative colitis patients are S2. Normal bone mineral density was detected in 2/8 case, osteopenia in 4/8 and osteoporosis in 2/8 patients. CONCLUSIONS: Within our cohort of patients with coeliac disease, inflammatory bowel disease was significantly more common (3,2 %) than in the general population. BioMed Central 2015-10-19 /pmc/articles/PMC4612406/ /pubmed/26481725 http://dx.doi.org/10.1186/s12876-015-0370-7 Text en © Kocsis et al. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Kocsis, Dorottya
Tóth, Zsuzsanna
Csontos, Ágnes A.
Miheller, Pál
Pák, Péter
Herszényi, László
Tóth, Miklós
Tulassay, Zsolt
Juhász, Márk
Prevalence of inflammatory bowel disease among coeliac disease patients in a Hungarian coeliac centre
title Prevalence of inflammatory bowel disease among coeliac disease patients in a Hungarian coeliac centre
title_full Prevalence of inflammatory bowel disease among coeliac disease patients in a Hungarian coeliac centre
title_fullStr Prevalence of inflammatory bowel disease among coeliac disease patients in a Hungarian coeliac centre
title_full_unstemmed Prevalence of inflammatory bowel disease among coeliac disease patients in a Hungarian coeliac centre
title_short Prevalence of inflammatory bowel disease among coeliac disease patients in a Hungarian coeliac centre
title_sort prevalence of inflammatory bowel disease among coeliac disease patients in a hungarian coeliac centre
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4612406/
https://www.ncbi.nlm.nih.gov/pubmed/26481725
http://dx.doi.org/10.1186/s12876-015-0370-7
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