The utility of transposon mutagenesis for cancer studies in the era of genome editing

The use of transposons as insertional mutagens to identify cancer genes in mice has generated a wealth of information over the past decade. Here, we discuss recent major advances in transposon-mediated insertional mutagenesis screens and compare this technology with other screening strategies.

Detalles Bibliográficos
Autores principales: DeNicola, Gina M., Karreth, Florian A., Adams, David J., Wong, Chi C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4612416/
https://www.ncbi.nlm.nih.gov/pubmed/26481584
http://dx.doi.org/10.1186/s13059-015-0794-y
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author DeNicola, Gina M.
Karreth, Florian A.
Adams, David J.
Wong, Chi C.
author_facet DeNicola, Gina M.
Karreth, Florian A.
Adams, David J.
Wong, Chi C.
author_sort DeNicola, Gina M.
collection PubMed
description The use of transposons as insertional mutagens to identify cancer genes in mice has generated a wealth of information over the past decade. Here, we discuss recent major advances in transposon-mediated insertional mutagenesis screens and compare this technology with other screening strategies.
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spelling pubmed-46124162015-10-22 The utility of transposon mutagenesis for cancer studies in the era of genome editing DeNicola, Gina M. Karreth, Florian A. Adams, David J. Wong, Chi C. Genome Biol Review The use of transposons as insertional mutagens to identify cancer genes in mice has generated a wealth of information over the past decade. Here, we discuss recent major advances in transposon-mediated insertional mutagenesis screens and compare this technology with other screening strategies. BioMed Central 2015-10-19 2015 /pmc/articles/PMC4612416/ /pubmed/26481584 http://dx.doi.org/10.1186/s13059-015-0794-y Text en © DeNicola et al. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
DeNicola, Gina M.
Karreth, Florian A.
Adams, David J.
Wong, Chi C.
The utility of transposon mutagenesis for cancer studies in the era of genome editing
title The utility of transposon mutagenesis for cancer studies in the era of genome editing
title_full The utility of transposon mutagenesis for cancer studies in the era of genome editing
title_fullStr The utility of transposon mutagenesis for cancer studies in the era of genome editing
title_full_unstemmed The utility of transposon mutagenesis for cancer studies in the era of genome editing
title_short The utility of transposon mutagenesis for cancer studies in the era of genome editing
title_sort utility of transposon mutagenesis for cancer studies in the era of genome editing
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4612416/
https://www.ncbi.nlm.nih.gov/pubmed/26481584
http://dx.doi.org/10.1186/s13059-015-0794-y
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