Cargando…

Allosteric interactions between receptor site 3 and 4 of voltage-gated sodium channels: a novel perspective for the underlying mechanism of scorpion sting-induced pain

BACKGROUND: BmK I, a site-3-specific modulator of voltage-gated sodium channels (VGSCs), causes pain and hyperalgesia in rats, while BmK IT2, a site-4-specific modulator of VGSCs, suppresses pain-related responses. A stronger pain-related effect has been previously attributed to Buthus martensi Kars...

Descripción completa

Detalles Bibliográficos
Autores principales:	Feng, Yi-Jun, Feng, Qi, Tao, Jie, Zhao, Rong, Ji, Yong-Hua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4612427/ https://www.ncbi.nlm.nih.gov/pubmed/26491429 http://dx.doi.org/10.1186/s40409-015-0043-6

Ejemplares similares

Allosteric interactions among voltage-sensor modules of sodium channels probed by scorpion toxin modifiers
por: Gurevitz, Michael, et al.
Publicado: (2022)

β-Scorpion Toxin Modifies Gating Transitions in All Four Voltage Sensors of the Sodium Channel
por: Campos, Fabiana V., et al.
Publicado: (2007)

Neurological perspectives on voltage-gated sodium channels
por: Eijkelkamp, Niels, et al.
Publicado: (2012)

Serotherapy against Voltage-Gated Sodium Channel-Targeting α-Toxins from Androctonus Scorpion Venom
por: Martin-Eauclaire, Marie-France, et al.
Publicado: (2019)

Voltage-Gated K(+)/Na(+) Channels and Scorpion Venom Toxins in Cancer
por: Díaz-García, Alexis, et al.
Publicado: (2020)

Integrated Allosteric Model of Voltage Gating of Hcn Channels
por: Altomare, Claudia, et al.
Publicado: (2001)

Voltage gated sodium channels as therapeutic targets for chronic pain
por: Ma, Renee Siu Yu, et al.
Publicado: (2019)

Fenestropathy of Voltage-Gated Sodium Channels
por: Gamal El-Din, Tamer M., et al.
Publicado: (2022)

Voltage-gated sodium channels assemble and gate as dimers
por: Clatot, Jérôme, et al.
Publicado: (2017)

An external sodium ion binding site controls allosteric gating in TRPV1 channels
por: Jara-Oseguera, Andres, et al.
Publicado: (2016)

Historical Perspective of the Characterization of Conotoxins Targeting Voltage-Gated Sodium Channels
por: Groome, James R.
Publicado: (2023)

Scorpion model of influenza A/H1N1: Hemagglutinin (HA) contains a scorpion toxin, binding to voltage-gated sodium Na+ channel: Na+ channel inhibitors as therapy
por: Tran, Guy Mong Ky, et al.
Publicado: (2010)

Excitability Constraints on Voltage-Gated Sodium Channels
por: Angelino, Elaine, et al.
Publicado: (2007)

Overview of the voltage-gated sodium channel family
por: Yu, Frank H, et al.
Publicado: (2003)

Voltage-gated sodium channels in the mammalian heart
por: Zimmer, Thomas, et al.
Publicado: (2014)

Cannabidiol interactions with voltage-gated sodium channels
por: Sait, Lily Goodyer, et al.
Publicado: (2020)

Calmodulin Interactions with Voltage-Gated Sodium Channels
por: Wu, Xin, et al.
Publicado: (2021)

Structural Advances in Voltage-Gated Sodium Channels
por: Jiang, Daohua, et al.
Publicado: (2022)

Phosphoinositide regulation of voltage-gated sodium channels
por: Short, Ben
Publicado: (2023)

Scorpion sting nephropathy
por: Viswanathan, Stalin, et al.
Publicado: (2011)

Treatment of Scorpion Stings
por: Rae, Manik Chand
Publicado: (1916)

Electricity for Scorpion Stings
por: Watkins, O.
Publicado: (1885)

Cure for Scorpion Sting
por: Banerjee, R. C.
Publicado: (1892)

Treatment of Scorpion Sting
por: Murthy, S. Sreemannarayana
Publicado: (1919)

Treatment of Scorpion Sting
por: Hall, G. C.
Publicado: (1876)

Treatment of Scorpion Stings
por: Saunders, W. E.
Publicado: (1876)

Treatment of Scorpion Stings
por: Kelly, P.
Publicado: (1876)

Treatment of Scorpion Stings
por: Pancholy, K. J.
Publicado: (1936)

Treatment of Scorpion Stings
por: Paparow, C.
Publicado: (1917)

Allosteric Voltage Gating of Potassium Channels II: Mslo Channel Gating Charge Movement in the Absence of Ca(2+)
por: Horrigan, Frank T., et al.
Publicado: (1999)

Neutralization of Gating Charges in Domain II of the Sodium Channel α Subunit Enhances Voltage-Sensor Trapping by a β-Scorpion Toxin
por: Cestèle, Sandrine, et al.
Publicado: (2001)

Post-translational modifications of voltage-gated sodium channels in chronic pain syndromes
por: Laedermann, Cedric J., et al.
Publicado: (2015)

Pandinus imperator scorpion venom blocks voltage-gated potassium channels in GH3 cells
por: Pappone, PA, et al.
Publicado: (1988)

Binding of scorpion toxin to receptor sites associated with sodium channels in frog muscle. Correlation of voltage-dependent binding with activation
Publicado: (1979)

Direct Evidence that Scorpion α-Toxins (Site-3) Modulate Sodium Channel Inactivation by Hindrance of Voltage-Sensor Movements
por: Ma, Zhongming, et al.
Publicado: (2013)

Identification and Characterization of Novel Proteins from Arizona Bark Scorpion Venom That Inhibit Nav1.8, a Voltage-Gated Sodium Channel Regulator of Pain Signaling
por: Abd El-Aziz, Tarek Mohamed, et al.
Publicado: (2021)

Propofol inhibits the voltage-gated sodium channel NaChBac at multiple sites
por: Wang, Yali, et al.
Publicado: (2018)

Druggability of Voltage-Gated Sodium Channels—Exploring Old and New Drug Receptor Sites
por: Wisedchaisri, Goragot, et al.
Publicado: (2022)

Voltage-gated sodium channels in taste bud cells
por: Gao, Na, et al.
Publicado: (2009)

THE CRYSTAL STRUCTURE OF A VOLTAGE-GATED SODIUM CHANNEL
por: Payandeh, Jian, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_1mu6o3amotlhe7m0aq8bp27sb8