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Allosteric interactions between receptor site 3 and 4 of voltage-gated sodium channels: a novel perspective for the underlying mechanism of scorpion sting-induced pain

BACKGROUND: BmK I, a site-3-specific modulator of voltage-gated sodium channels (VGSCs), causes pain and hyperalgesia in rats, while BmK IT2, a site-4-specific modulator of VGSCs, suppresses pain-related responses. A stronger pain-related effect has been previously attributed to Buthus martensi Kars...

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Detalles Bibliográficos
Autores principales:	Feng, Yi-Jun, Feng, Qi, Tao, Jie, Zhao, Rong, Ji, Yong-Hua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4612427/ https://www.ncbi.nlm.nih.gov/pubmed/26491429 http://dx.doi.org/10.1186/s40409-015-0043-6

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