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CRISPR/Cas9-mediated heterozygous knockout of the autism gene CHD8 and characterization of its transcriptional networks in neurodevelopment

BACKGROUND: Disruptive mutation in the CHD8 gene is one of the top genetic risk factors in autism spectrum disorders (ASDs). Previous analyses of genome-wide CHD8 occupancy and reduced expression of CHD8 by shRNA knockdown in committed neural cells showed that CHD8 regulates multiple cell processes...

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Detalles Bibliográficos
Autores principales:	Wang, Ping, Lin, Mingyan, Pedrosa, Erika, Hrabovsky, Anastasia, Zhang, Zheng, Guo, Wenjun, Lachman, Herbert M., Zheng, Deyou
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4612430/ https://www.ncbi.nlm.nih.gov/pubmed/26491539 http://dx.doi.org/10.1186/s13229-015-0048-6

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