Hepatic progenitor cells of biliary origin with liver repopulation capacity

Hepatocytes and cholangiocytes self renew following liver injury. Following severe injury hepatocytes are increasingly senescent, whether Hepatic Progenitor Cells (HPCs) then contribute to liver regeneration is unclear. Here, we describe a mouse model where Mdm2 is inducibly deleted in over 98% of h...

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Detalles Bibliográficos
Autores principales: Lu, Wei-Yu, Bird, Thomas G, Boulter, Luke, Tsuchiya, Atsunori, Cole, Alicia M, Hay, Trevor, Guest, Rachel V, Wojtacha, Davina, Man, Tak Yung, Mackinnon, Alison, Ridgway, Rachel A, Kendall, Timothy, Williams, Michael J, Jamieson, Thomas, Raven, Alex, Hay, David C, Iredale, John P, Clarke, Alan R, Sansom, Owen J, Forbes, Stuart J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4612439/
https://www.ncbi.nlm.nih.gov/pubmed/26192438
http://dx.doi.org/10.1038/ncb3203

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