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Complementary Patterns of Direct Amygdala and Hippocampal Projections to the Macaque Prefrontal Cortex
The projections from the amygdala and hippocampus (including subiculum and presubiculum) to prefrontal cortex were compared using anterograde tracers injected into macaque monkeys (Macaca fascicularis, Macaca mulatta). Almost all prefrontal areas were found to receive some amygdala inputs. These con...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4612443/ https://www.ncbi.nlm.nih.gov/pubmed/25715284 http://dx.doi.org/10.1093/cercor/bhv019 |
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author | Aggleton, John P. Wright, Nicholas F. Rosene, Douglas L. Saunders, Richard C. |
author_facet | Aggleton, John P. Wright, Nicholas F. Rosene, Douglas L. Saunders, Richard C. |
author_sort | Aggleton, John P. |
collection | PubMed |
description | The projections from the amygdala and hippocampus (including subiculum and presubiculum) to prefrontal cortex were compared using anterograde tracers injected into macaque monkeys (Macaca fascicularis, Macaca mulatta). Almost all prefrontal areas were found to receive some amygdala inputs. These connections, which predominantly arose from the intermediate and magnocellular basal nucleus, were particularly dense in parts of the medial and orbital prefrontal cortex. Contralateral inputs were not, however, observed. The hippocampal projections to prefrontal areas were far more restricted, being confined to the ipsilateral medial and orbital prefrontal cortex (within areas 11, 13, 14, 24a, 32, and 25). These hippocampal projections principally arose from the subiculum, with the fornix providing the sole route. Thus, while the lateral prefrontal cortex essentially receives only amygdala inputs, the orbital prefrontal cortex receives both amygdala and hippocampal inputs, though these typically target different areas. Only in medial prefrontal cortex do direct inputs from both structures terminate in common sites. But, even when convergence occurs within an area, the projections predominantly terminate in different lamina (hippocampal inputs to layer III and amygdala inputs to layers I, II, and VI). The resulting segregation of prefrontal inputs could enable the parallel processing of different information types in prefrontal cortex. |
format | Online Article Text |
id | pubmed-4612443 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-46124432015-10-22 Complementary Patterns of Direct Amygdala and Hippocampal Projections to the Macaque Prefrontal Cortex Aggleton, John P. Wright, Nicholas F. Rosene, Douglas L. Saunders, Richard C. Cereb Cortex Articles The projections from the amygdala and hippocampus (including subiculum and presubiculum) to prefrontal cortex were compared using anterograde tracers injected into macaque monkeys (Macaca fascicularis, Macaca mulatta). Almost all prefrontal areas were found to receive some amygdala inputs. These connections, which predominantly arose from the intermediate and magnocellular basal nucleus, were particularly dense in parts of the medial and orbital prefrontal cortex. Contralateral inputs were not, however, observed. The hippocampal projections to prefrontal areas were far more restricted, being confined to the ipsilateral medial and orbital prefrontal cortex (within areas 11, 13, 14, 24a, 32, and 25). These hippocampal projections principally arose from the subiculum, with the fornix providing the sole route. Thus, while the lateral prefrontal cortex essentially receives only amygdala inputs, the orbital prefrontal cortex receives both amygdala and hippocampal inputs, though these typically target different areas. Only in medial prefrontal cortex do direct inputs from both structures terminate in common sites. But, even when convergence occurs within an area, the projections predominantly terminate in different lamina (hippocampal inputs to layer III and amygdala inputs to layers I, II, and VI). The resulting segregation of prefrontal inputs could enable the parallel processing of different information types in prefrontal cortex. Oxford University Press 2015-11 2015-02-24 /pmc/articles/PMC4612443/ /pubmed/25715284 http://dx.doi.org/10.1093/cercor/bhv019 Text en © The Author 2015. Published by Oxford University Press http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Articles Aggleton, John P. Wright, Nicholas F. Rosene, Douglas L. Saunders, Richard C. Complementary Patterns of Direct Amygdala and Hippocampal Projections to the Macaque Prefrontal Cortex |
title | Complementary Patterns of Direct Amygdala and Hippocampal Projections to the Macaque Prefrontal Cortex |
title_full | Complementary Patterns of Direct Amygdala and Hippocampal Projections to the Macaque Prefrontal Cortex |
title_fullStr | Complementary Patterns of Direct Amygdala and Hippocampal Projections to the Macaque Prefrontal Cortex |
title_full_unstemmed | Complementary Patterns of Direct Amygdala and Hippocampal Projections to the Macaque Prefrontal Cortex |
title_short | Complementary Patterns of Direct Amygdala and Hippocampal Projections to the Macaque Prefrontal Cortex |
title_sort | complementary patterns of direct amygdala and hippocampal projections to the macaque prefrontal cortex |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4612443/ https://www.ncbi.nlm.nih.gov/pubmed/25715284 http://dx.doi.org/10.1093/cercor/bhv019 |
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