Platelets Contribute to BBB Disruption Induced by HIV and Alcohol

The role of platelets in the neurological diseases that underlie cognitive impairment has attracted increasing attention in recent years. Multiple pathways in platelets contribute to host defenses, as well as to CNS function. In the current study, we hypothesize that the Blood Brain Barrier (BBB) is...

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Autores principales: Nair, Madhavan, Maria, Jose MB, Agudelo, Marisela, Yndart, Adriana, Vargas-Rivera, Mayra E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4612493/
https://www.ncbi.nlm.nih.gov/pubmed/26501067
http://dx.doi.org/10.4172/2329-6488.1000182
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author Nair, Madhavan
Maria, Jose MB
Agudelo, Marisela
Yndart, Adriana
Vargas-Rivera, Mayra E
author_facet Nair, Madhavan
Maria, Jose MB
Agudelo, Marisela
Yndart, Adriana
Vargas-Rivera, Mayra E
author_sort Nair, Madhavan
collection PubMed
description The role of platelets in the neurological diseases that underlie cognitive impairment has attracted increasing attention in recent years. Multiple pathways in platelets contribute to host defenses, as well as to CNS function. In the current study, we hypothesize that the Blood Brain Barrier (BBB) is disrupted when exposed to platelets from patients with triple Co-morbidity (hazardous alcohol users+ HIV+ thrombocytopenia), compared to those with dual, single or no morbidity (HIV only, alcohol only or healthy controls).
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spelling pubmed-46124932016-01-31 Platelets Contribute to BBB Disruption Induced by HIV and Alcohol Nair, Madhavan Maria, Jose MB Agudelo, Marisela Yndart, Adriana Vargas-Rivera, Mayra E J Alcohol Drug Depend Article The role of platelets in the neurological diseases that underlie cognitive impairment has attracted increasing attention in recent years. Multiple pathways in platelets contribute to host defenses, as well as to CNS function. In the current study, we hypothesize that the Blood Brain Barrier (BBB) is disrupted when exposed to platelets from patients with triple Co-morbidity (hazardous alcohol users+ HIV+ thrombocytopenia), compared to those with dual, single or no morbidity (HIV only, alcohol only or healthy controls). 2015-01-19 2015-02 /pmc/articles/PMC4612493/ /pubmed/26501067 http://dx.doi.org/10.4172/2329-6488.1000182 Text en http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Article
Nair, Madhavan
Maria, Jose MB
Agudelo, Marisela
Yndart, Adriana
Vargas-Rivera, Mayra E
Platelets Contribute to BBB Disruption Induced by HIV and Alcohol
title Platelets Contribute to BBB Disruption Induced by HIV and Alcohol
title_full Platelets Contribute to BBB Disruption Induced by HIV and Alcohol
title_fullStr Platelets Contribute to BBB Disruption Induced by HIV and Alcohol
title_full_unstemmed Platelets Contribute to BBB Disruption Induced by HIV and Alcohol
title_short Platelets Contribute to BBB Disruption Induced by HIV and Alcohol
title_sort platelets contribute to bbb disruption induced by hiv and alcohol
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4612493/
https://www.ncbi.nlm.nih.gov/pubmed/26501067
http://dx.doi.org/10.4172/2329-6488.1000182
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AT yndartadriana plateletscontributetobbbdisruptioninducedbyhivandalcohol
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