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Combinatorial RNA Interference Therapy Prevents Selection of Pre-existing HBV Variants in Human Liver Chimeric Mice

Selection of escape mutants with mutations within the target sequence could abolish the antiviral RNA interference activity. Here, we investigated the impact of a pre-existing shRNA-resistant HBV variant on the efficacy of shRNA therapy. We previously identified a highly potent shRNA, S1, which, whe...

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Detalles Bibliográficos
Autores principales:	Shih, Yao-Ming, Sun, Cheng-Pu, Chou, Hui-Hsien, Wu, Tzu-Hui, Chen, Chun-Chi, Wu, Ping-Yi, Enya Chen, Yu-Chen, Bissig, Karl-Dimiter, Tao, Mi-Hua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4612501/ https://www.ncbi.nlm.nih.gov/pubmed/26482836 http://dx.doi.org/10.1038/srep15259

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