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Oral clindamycin causing acute cholestatic hepatitis without ductopenia: a brief review of idiosyncratic drug-induced liver injury and a case report

Clindamycin is a lincosamide antibiotic active against most of the anaerobes, protozoans, and Gram-positive bacteria, including community-acquired methicillin-resistant Staphylococcus aureus. Its use has increased greatly in the recent past due to wide spectrum of activity and good bioavailability i...

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Detalles Bibliográficos
Autores principales: Moole, Harsha, Ahmed, Zohair, Saxena, Nibha, Puli, Srinivas R., Dhillon, Sonu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Co-Action Publishing 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4612703/
https://www.ncbi.nlm.nih.gov/pubmed/26486111
http://dx.doi.org/10.3402/jchimp.v5.28746
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author Moole, Harsha
Ahmed, Zohair
Saxena, Nibha
Puli, Srinivas R.
Dhillon, Sonu
author_facet Moole, Harsha
Ahmed, Zohair
Saxena, Nibha
Puli, Srinivas R.
Dhillon, Sonu
author_sort Moole, Harsha
collection PubMed
description Clindamycin is a lincosamide antibiotic active against most of the anaerobes, protozoans, and Gram-positive bacteria, including community-acquired methicillin-resistant Staphylococcus aureus. Its use has increased greatly in the recent past due to wide spectrum of activity and good bioavailability in oral form. Close to 20% of the patients taking clindamycin experience diarrhea as the most common side effect. Hepatotoxicity is a rare side effect. Systemic clindamycin therapy has been linked to two forms of hepatotoxicity: transient serum aminotransferase elevation and an acute idiosyncratic liver injury that occurs 1–3 weeks after starting therapy. This article is a case report of oral clindamycin induced acute symptomatic cholestatic hepatitis and a brief review of the topic.
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spelling pubmed-46127032015-11-23 Oral clindamycin causing acute cholestatic hepatitis without ductopenia: a brief review of idiosyncratic drug-induced liver injury and a case report Moole, Harsha Ahmed, Zohair Saxena, Nibha Puli, Srinivas R. Dhillon, Sonu J Community Hosp Intern Med Perspect Review Article Clindamycin is a lincosamide antibiotic active against most of the anaerobes, protozoans, and Gram-positive bacteria, including community-acquired methicillin-resistant Staphylococcus aureus. Its use has increased greatly in the recent past due to wide spectrum of activity and good bioavailability in oral form. Close to 20% of the patients taking clindamycin experience diarrhea as the most common side effect. Hepatotoxicity is a rare side effect. Systemic clindamycin therapy has been linked to two forms of hepatotoxicity: transient serum aminotransferase elevation and an acute idiosyncratic liver injury that occurs 1–3 weeks after starting therapy. This article is a case report of oral clindamycin induced acute symptomatic cholestatic hepatitis and a brief review of the topic. Co-Action Publishing 2015-10-19 /pmc/articles/PMC4612703/ /pubmed/26486111 http://dx.doi.org/10.3402/jchimp.v5.28746 Text en © 2015 Harsha Moole et al. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License, permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Moole, Harsha
Ahmed, Zohair
Saxena, Nibha
Puli, Srinivas R.
Dhillon, Sonu
Oral clindamycin causing acute cholestatic hepatitis without ductopenia: a brief review of idiosyncratic drug-induced liver injury and a case report
title Oral clindamycin causing acute cholestatic hepatitis without ductopenia: a brief review of idiosyncratic drug-induced liver injury and a case report
title_full Oral clindamycin causing acute cholestatic hepatitis without ductopenia: a brief review of idiosyncratic drug-induced liver injury and a case report
title_fullStr Oral clindamycin causing acute cholestatic hepatitis without ductopenia: a brief review of idiosyncratic drug-induced liver injury and a case report
title_full_unstemmed Oral clindamycin causing acute cholestatic hepatitis without ductopenia: a brief review of idiosyncratic drug-induced liver injury and a case report
title_short Oral clindamycin causing acute cholestatic hepatitis without ductopenia: a brief review of idiosyncratic drug-induced liver injury and a case report
title_sort oral clindamycin causing acute cholestatic hepatitis without ductopenia: a brief review of idiosyncratic drug-induced liver injury and a case report
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4612703/
https://www.ncbi.nlm.nih.gov/pubmed/26486111
http://dx.doi.org/10.3402/jchimp.v5.28746
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