Colitis Following Initiation of Sofosbuvir and Simeprevir for Genotype 1 Hepatitis C

Sofosbuvir and simeprevir are used for the treatment of chronic hepatitis C (HCV) genotype 1. Both drugs have been well-tolerated, with diarrhea noted in 6% cases with sofosbuvir, 16% with sofosbuvir plus simeprevir, and 0% with simeprevir. No prior reports exist of colitis secondary to either drug...

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Autores principales: Sarkar, Souvik, Mitchell, Kisha A., Lim, Joseph K., Oikonomou, Ioannis, Jakab, Simona
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American College of Gastroenterology 2015
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4612757/
https://www.ncbi.nlm.nih.gov/pubmed/26504877
http://dx.doi.org/10.14309/crj.2015.96
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author Sarkar, Souvik
Mitchell, Kisha A.
Lim, Joseph K.
Oikonomou, Ioannis
Jakab, Simona
author_facet Sarkar, Souvik
Mitchell, Kisha A.
Lim, Joseph K.
Oikonomou, Ioannis
Jakab, Simona
author_sort Sarkar, Souvik
collection PubMed
description Sofosbuvir and simeprevir are used for the treatment of chronic hepatitis C (HCV) genotype 1. Both drugs have been well-tolerated, with diarrhea noted in 6% cases with sofosbuvir, 16% with sofosbuvir plus simeprevir, and 0% with simeprevir. No prior reports exist of colitis secondary to either drug or their combination. We report a patient with no prior history of inflammatory bowel disease who developed significant bloody diarrhea within 2 weeks of sofosbuvir/simeprevir initiation. Colonoscopy and biopsy confirmed pancolitis, which responded to mesalamine and completion of sofosbuvir/simeprevir.
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spelling pubmed-46127572015-10-26 Colitis Following Initiation of Sofosbuvir and Simeprevir for Genotype 1 Hepatitis C Sarkar, Souvik Mitchell, Kisha A. Lim, Joseph K. Oikonomou, Ioannis Jakab, Simona ACG Case Rep J Case Report Sofosbuvir and simeprevir are used for the treatment of chronic hepatitis C (HCV) genotype 1. Both drugs have been well-tolerated, with diarrhea noted in 6% cases with sofosbuvir, 16% with sofosbuvir plus simeprevir, and 0% with simeprevir. No prior reports exist of colitis secondary to either drug or their combination. We report a patient with no prior history of inflammatory bowel disease who developed significant bloody diarrhea within 2 weeks of sofosbuvir/simeprevir initiation. Colonoscopy and biopsy confirmed pancolitis, which responded to mesalamine and completion of sofosbuvir/simeprevir. American College of Gastroenterology 2015-10-09 /pmc/articles/PMC4612757/ /pubmed/26504877 http://dx.doi.org/10.14309/crj.2015.96 Text en Copyright © Sarkar et al. This is an open-access article. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/
spellingShingle Case Report
Sarkar, Souvik
Mitchell, Kisha A.
Lim, Joseph K.
Oikonomou, Ioannis
Jakab, Simona
Colitis Following Initiation of Sofosbuvir and Simeprevir for Genotype 1 Hepatitis C
title Colitis Following Initiation of Sofosbuvir and Simeprevir for Genotype 1 Hepatitis C
title_full Colitis Following Initiation of Sofosbuvir and Simeprevir for Genotype 1 Hepatitis C
title_fullStr Colitis Following Initiation of Sofosbuvir and Simeprevir for Genotype 1 Hepatitis C
title_full_unstemmed Colitis Following Initiation of Sofosbuvir and Simeprevir for Genotype 1 Hepatitis C
title_short Colitis Following Initiation of Sofosbuvir and Simeprevir for Genotype 1 Hepatitis C
title_sort colitis following initiation of sofosbuvir and simeprevir for genotype 1 hepatitis c
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4612757/
https://www.ncbi.nlm.nih.gov/pubmed/26504877
http://dx.doi.org/10.14309/crj.2015.96
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