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Disseminated Tuberculosis in a Patient Taking Anti-TNF Therapy for Crohn's Disease

A man in his sixth decade with Crohn's colitis and who had been taking infliximab for 18 months presented with fever and weight loss. Chest CT showed numerous nodules in both lungs, and sputum culture grew Mycobacterium tuberculosis. Colonoscopy showed circumferential ulcerations from the cecum...

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Detalles Bibliográficos
Autores principales: Wang, Ming-Hsi, Liu, Xiuli, Shen, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American College of Gastroenterology 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4612758/
https://www.ncbi.nlm.nih.gov/pubmed/26504878
http://dx.doi.org/10.14309/crj.2015.97
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author Wang, Ming-Hsi
Liu, Xiuli
Shen, Bo
author_facet Wang, Ming-Hsi
Liu, Xiuli
Shen, Bo
author_sort Wang, Ming-Hsi
collection PubMed
description A man in his sixth decade with Crohn's colitis and who had been taking infliximab for 18 months presented with fever and weight loss. Chest CT showed numerous nodules in both lungs, and sputum culture grew Mycobacterium tuberculosis. Colonoscopy showed circumferential ulcerations from the cecum to the descending colon, and biopsies showed extensive granulomas with central necrosis, positive for acid-fast bacteria. Brain MRI revealed a thalamic ring-enhanced mass with edema, consistent with tuberculoma. Clinicians should be aware of the appropriate screening and close monitoring of tuberculosis before and during anti-tumor necrosis factor (TNF) therapy.
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spelling pubmed-46127582015-10-26 Disseminated Tuberculosis in a Patient Taking Anti-TNF Therapy for Crohn's Disease Wang, Ming-Hsi Liu, Xiuli Shen, Bo ACG Case Rep J Case Report A man in his sixth decade with Crohn's colitis and who had been taking infliximab for 18 months presented with fever and weight loss. Chest CT showed numerous nodules in both lungs, and sputum culture grew Mycobacterium tuberculosis. Colonoscopy showed circumferential ulcerations from the cecum to the descending colon, and biopsies showed extensive granulomas with central necrosis, positive for acid-fast bacteria. Brain MRI revealed a thalamic ring-enhanced mass with edema, consistent with tuberculoma. Clinicians should be aware of the appropriate screening and close monitoring of tuberculosis before and during anti-tumor necrosis factor (TNF) therapy. American College of Gastroenterology 2015-10-09 /pmc/articles/PMC4612758/ /pubmed/26504878 http://dx.doi.org/10.14309/crj.2015.97 Text en Copyright © Wang et al. This is an open-access article. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/
spellingShingle Case Report
Wang, Ming-Hsi
Liu, Xiuli
Shen, Bo
Disseminated Tuberculosis in a Patient Taking Anti-TNF Therapy for Crohn's Disease
title Disseminated Tuberculosis in a Patient Taking Anti-TNF Therapy for Crohn's Disease
title_full Disseminated Tuberculosis in a Patient Taking Anti-TNF Therapy for Crohn's Disease
title_fullStr Disseminated Tuberculosis in a Patient Taking Anti-TNF Therapy for Crohn's Disease
title_full_unstemmed Disseminated Tuberculosis in a Patient Taking Anti-TNF Therapy for Crohn's Disease
title_short Disseminated Tuberculosis in a Patient Taking Anti-TNF Therapy for Crohn's Disease
title_sort disseminated tuberculosis in a patient taking anti-tnf therapy for crohn's disease
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4612758/
https://www.ncbi.nlm.nih.gov/pubmed/26504878
http://dx.doi.org/10.14309/crj.2015.97
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