Lymphoma Remission by Interferon-Free HCV Eradication Without Chemotherapy

Epidemiologic studies have suggested an association between hepatitis C virus (HCV) infection and antigendriven lymphoproliferative disorders, in particular marginal zone lymphomas. Antiviral therapy has been shown to exert an anti-lymphoma effect in these indolent B-cell lymphoproliferations, with...

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Autores principales: Lim, Lucy Y., La, Danie, Cserti-Gazdewich, Christine M., Shah, Hemant
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American College of Gastroenterology 2015
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4612765/
https://www.ncbi.nlm.nih.gov/pubmed/26504885
http://dx.doi.org/10.14309/crj.2015.104
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author Lim, Lucy Y.
La, Danie
Cserti-Gazdewich, Christine M.
Shah, Hemant
author_facet Lim, Lucy Y.
La, Danie
Cserti-Gazdewich, Christine M.
Shah, Hemant
author_sort Lim, Lucy Y.
collection PubMed
description Epidemiologic studies have suggested an association between hepatitis C virus (HCV) infection and antigendriven lymphoproliferative disorders, in particular marginal zone lymphomas. Antiviral therapy has been shown to exert an anti-lymphoma effect in these indolent B-cell lymphoproliferations, with survival gains observed. However, these protocols have traditionally incorporated interferon. We describe a patient with chronic hepatitis C, immune thrombocytopenia, and splenic marginal zone lymphoma who, after eradication of HCV with sofosbuvir and ribavirin, exhibited complete remission of both hematologic conditions. With the numerous new potent drugs currently available, the future looks positive with highly efficacious interferon-free regimens for HCV therapy.
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spelling pubmed-46127652015-10-26 Lymphoma Remission by Interferon-Free HCV Eradication Without Chemotherapy Lim, Lucy Y. La, Danie Cserti-Gazdewich, Christine M. Shah, Hemant ACG Case Rep J Case Report Epidemiologic studies have suggested an association between hepatitis C virus (HCV) infection and antigendriven lymphoproliferative disorders, in particular marginal zone lymphomas. Antiviral therapy has been shown to exert an anti-lymphoma effect in these indolent B-cell lymphoproliferations, with survival gains observed. However, these protocols have traditionally incorporated interferon. We describe a patient with chronic hepatitis C, immune thrombocytopenia, and splenic marginal zone lymphoma who, after eradication of HCV with sofosbuvir and ribavirin, exhibited complete remission of both hematologic conditions. With the numerous new potent drugs currently available, the future looks positive with highly efficacious interferon-free regimens for HCV therapy. American College of Gastroenterology 2015-10-09 /pmc/articles/PMC4612765/ /pubmed/26504885 http://dx.doi.org/10.14309/crj.2015.104 Text en Copyright © Lim et al. This is an open-access article. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/
spellingShingle Case Report
Lim, Lucy Y.
La, Danie
Cserti-Gazdewich, Christine M.
Shah, Hemant
Lymphoma Remission by Interferon-Free HCV Eradication Without Chemotherapy
title Lymphoma Remission by Interferon-Free HCV Eradication Without Chemotherapy
title_full Lymphoma Remission by Interferon-Free HCV Eradication Without Chemotherapy
title_fullStr Lymphoma Remission by Interferon-Free HCV Eradication Without Chemotherapy
title_full_unstemmed Lymphoma Remission by Interferon-Free HCV Eradication Without Chemotherapy
title_short Lymphoma Remission by Interferon-Free HCV Eradication Without Chemotherapy
title_sort lymphoma remission by interferon-free hcv eradication without chemotherapy
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4612765/
https://www.ncbi.nlm.nih.gov/pubmed/26504885
http://dx.doi.org/10.14309/crj.2015.104
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