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A Novel Human scFv Library with Non-Combinatorial Synthetic CDR Diversity
The present work describes the construction and validation of a human scFv library with a novel design approach to synthetic complementarity determining region (CDR) diversification. The advantage of synthetic antibody libraries includes the possibility of exerting fine control over factors like fra...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613135/ https://www.ncbi.nlm.nih.gov/pubmed/26484868 http://dx.doi.org/10.1371/journal.pone.0141045 |