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HMGB1 Contributes to the Expression of P-Glycoprotein in Mouse Epileptic Brain through Toll-Like Receptor 4 and Receptor for Advanced Glycation End Products
The objective of the present study was to investigate the role of high-mobility group box-1 (HMGB1) in the seizure-induced P-glycoprotein (P-gp) overexpression and the underlying mechanism. Kainic acid (KA)-induced mouse seizure model was used for in vivo experiments. Male C57BL/6 mice were divided...
Autores principales: | Chen, Yan, Huang, Xian-Jing, Yu, Nian, Xie, Yuan, Zhang, Kang, Wen, Fang, Liu, Hao, Di, Qing |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613137/ https://www.ncbi.nlm.nih.gov/pubmed/26485677 http://dx.doi.org/10.1371/journal.pone.0140918 |
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